Evidence map›Paper›PMID 30400244›Full record

ArticleMolecules (Basel, Switzerland)2018

Discovery of 3-Amino-2-Hydroxypropoxyisoflavone Derivatives as Potential Anti-HCV Agents.

Jin-Ching Lee, Chun-Kuang Lin, Chin-Kai Tseng, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases.Journal of Zhejiang University. Science. B · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jin-Ching LeeDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. jclee@kmu.edu.tw.
Chun-Kuang LinDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. crystalsoul35@gmail.com.
Chin-Kai TsengDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. jimmytseng@biosidsco.com.
Yeh-Long ChenDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. yeloch@kmu.edu.tw.
Cherng-Chyi TzengDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. tzengch@kmu.edu.tw.
Chih-Hua TsengSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. chihhua@kmu.edu.tw.ORCID 0000-0001-7392-7104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthesis and anti-hepatitis C virus (anti-HCV) effects of certain 3-amino-2-hydroxy-propoxy isoflavone derivatives,

Indexed as

Antiviral AgentsCell LineCells, CulturedGene Expression RegulationHeme Oxygenase-1HepacivirusHepatitis CHumansInhibitory Concentration 50IsoflavonesMagnetic Resonance SpectroscopyMolecular StructureNF-E2-Related Factor 2Structure-Activity RelationshipVirus ReplicationAntiviral AgentsHeme Oxygenase-1HMOX1 protein, humanisoflavanoneIsoflavonesNFE2L2 protein, humanNF-E2-Related Factor 23-amino-2-hydroxypropoxyisoflavonescytotoxicityhepatitis C virusribavirin

Identifiers

PMID30400244
PMCPMC6278568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.