Evidence map›Paper›PMID 30400228›Full record

ArticleInternational journal of molecular sciences2018

Gene and Protein Expression Profile of Selected Molecular Targets Mediating Electrophysiological Function in

Karan R Chadda, Charlotte E Edling, Haseeb Valli, Shiraz Ahmad, Christopher L-H Huang, Kamalan Jeevaratnam

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Karan R ChaddaFaculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK. krchadda95@gmail.com.
Charlotte E EdlingFaculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK. c.edling@surrey.ac.uk.
Haseeb ValliPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. haseeb.valli@gmail.com.
Shiraz AhmadPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. sa416@cam.ac.uk.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. clh11@cam.ac.uk.
Kamalan JeevaratnamFaculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK. drkamalanjeeva@gmail.com.ORCID 0000-0002-6232-388X
University of Cambridge · GBUniversity of Surrey · GB

Funding

British Heart Foundation PG/14/79/31102 and PG/15/12/31280Medical Research Council MR/M001288/1Wellcome Trust 105727/Z/14/Z
6 · The paper itself

Abstract

Increases in the prevalence of obesity, insulin resistance, and metabolic syndrome has led to the increase of atrial fibrillation (AF) cases in the developed world. These AF risk factors are associated with mitochondrial dysfunction, previously modelled using peroxisome proliferator activated receptor-γ (PPARγ) coactivator-1 (

Indexed as

Gene Expression ProfilingAction PotentialsAnimalsCalciumCyclic AMPElectrophysiological PhenomenaGene Expression RegulationHeart AtriaHeart Conduction SystemHomeostasisIon ChannelsMice, Inbred C57BLMyocytes, CardiacSignal TransductionSodium-Potassium-Exchanging ATPaseTranscription FactorsCalciumCyclic AMPIon Channelsperoxisome-proliferator-activated receptor-gamma coactivator-1Sodium-Potassium-Exchanging ATPaseTranscription Factorsarrhythmiasion channelsmitochondriaperoxisome proliferator activated receptor-γ (PPARγ) coactivator-1 transcriptional coactivator (Pgc-1)quantitative PCR

Identifiers

PMID30400228
PMCPMC6274828
OpenAlexW2899358143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.