ArticleJournal of Alzheimer's disease : JAD2018
Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the Risks of Motor Vehicle Crashes Associated with Psychiatric Disorders.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Pooled it
- Neurophysiological Characteristics Associated with Driving Abilities in Older Adults: A Scoping Review.Journal of clinical medicine · 2026Review
- White Matter Hyperintensity Burden and Decline in Driving Performance Among Older Adults.JAMA network open · 2026Article
- Depressive Symptoms Correlate With Tau Accumulation Rates in Amyloid Positive Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Effects of Smartphone-Based Hospital-Family Transitional Care on Symptom Burden and Quality of Life in Elderly Patients with Depression.Alpha psychiatry · 2025Article
- Identifying major depressive disorder in older adults through naturalistic driving behaviors and machine learning.NPJ digital medicine · 2025Article
- Major Depressive Disorder and Driving Behavior Among Older Adults.JAMA network open · 2024Article
- Association of Depression and Antidepressant Use With Driving Behaviors in Older Adults: A LongROAD Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Article
- From Mild Cognitive Impairment to Dementia: The Impact of Comorbid Conditions on Disease Conversion.Biomedicines · 2024Article
- Predicting driving decline and assessing crash risk in a globally aging population.Arquivos de neuro-psiquiatria · 2022Article
- Using Naturalistic Driving Data to Predict Mild Cognitive Impairment and Dementia: Preliminary Findings from the Longitudinal Research on Aging Drivers (LongROAD) Study.Geriatrics (Basel, Switzerland) · 2021Article
- The Impact of Disease Comorbidities in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundSymptomatic Alzheimer's disease (AD) and depression independently increase crash risk. Additionally, depression is both a risk factor for and a consequence of AD.
objectiveTo examine whether a depression diagnosis, antidepressant use, and preclinical AD are associated with driving decline among cognitively normal older adults.
methodsCognitively normal participants, age ≥65, were enrolled. Cox proportional hazards models evaluated whether a depression diagnosis, depressive symptoms (Geriatric Depression Scale), antidepressant use, cerebrospinal fluid (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181]), and amyloid imaging biomarkers (Pittsburgh Compound B and Florbetapir) were associated with time to receiving a rating of marginal/fail on a road test. Age was adjusted for in all models.
resultsData were available from 131 participants with age ranging from 65.4 to 88.2 years and mean follow up of 2.4 years (SD = 1.0). A depression diagnosis was associated with a faster time to receiving a marginal/fail rating on a road test and antidepressant use (p = 0.024, HR = 2.62). Depression diagnosis and CSF and amyloid PET imaging biomarkers were associated with driving performance on the road test (p≤0.05, HR = 2.51-3.15). In the CSF ptau181 model, depression diagnosis (p = 0.031, HR = 2.51) and antidepressant use (p = 0.037, HR = 2.50) were statistically significant predictors. There were no interaction effects between depression diagnosis, antidepressant use, and biomarker groups. Depressive symptomology was not a statistically significant predictor of driving performance.
conclusionsWhile, as previously shown, preclinical AD alone predicts a faster time to receiving a marginal/fail rating, these results suggest that also having a diagnosis of depression accelerates the onset of driving problems in cognitively normal older adults.
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