Evidence map›Paper›PMID 30399318›Full record

ArticleACS chemical neuroscience2019

Azelnidipine Attenuates the Oxidative and NFκB Pathways in Amyloid-β-Stimulated Cerebral Endothelial Cells.

Tao Teng, Devin M Ridgley, Andrey Tsoy, Grace Y Sun, Sholpan Askarova, James C Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Current updates on latest basic research of scientific relevance in hypertensive dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Tao TengRichard and Loan Hill Department of Bioengineering , University of Illinois at Chicago , 851 South Morgan Street, MC 063 , Chicago , Illinois 60607 , United States.
Devin M RidgleyRichard and Loan Hill Department of Bioengineering , University of Illinois at Chicago , 851 South Morgan Street, MC 063 , Chicago , Illinois 60607 , United States.
Andrey TsoyNational Laboratory Astana , Nazarbayev University , Astana , Kazakhstan 010000.
Grace Y SunDepartment of Biochemistry , University of Missouri , Columbia , Missouri 65211 , United States.
Sholpan AskarovaNational Laboratory Astana , Nazarbayev University , Astana , Kazakhstan 010000.
James C LeeRichard and Loan Hill Department of Bioengineering , University of Illinois at Chicago , 851 South Morgan Street, MC 063 , Chicago , Illinois 60607 , United States.ORCID 0000-0002-7173-4875
University of Illinois Chicago · USNazarbayev University · KZUniversity of Missouri · US

Funding

Roles of Tau Oligomers in Alzheimer's VasculopathyR01AG044404 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEE, JAMES C · 2014 to 2024
$3.5M
NIA NIH HHS R01 AG044404
6 · The paper itself

Abstract

Cerebral amyloid angiopathy (CAA), a condition depicting cerebrovascular accumulation of amyloid β-peptide (Aβ), is a common pathological manifestation in Alzheimer's disease (AD). In this study, we investigated the effects of Azelnidipine (ALP), a dihydropyridine calcium channel blocker known for its treatment of hypertension, on oligomeric Aβ (oAβ)-induced calcium influx and its downstream pathway in immortalized mouse cerebral endothelial cells (bEND3). We found that ALP attenuated oAβ-induced calcium influx, superoxide anion production, and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and calcium-dependent cytosolic phospholipase A

Indexed as

Amyloid beta-PeptidesAnimalsAzetidinecarboxylic AcidCalcium Channel BlockersCell Line, TransformedCerebral Amyloid AngiopathyCerebral CortexDihydropyridinesEndothelial CellsMiceNF-kappa BOxidative StressSignal TransductionAmyloid beta-PeptidesazelnidipineAzetidinecarboxylic AcidCalcium Channel BlockersDihydropyridinesNF-kappa BAlzheimer’sAmyloid-β peptideAzelnidipinecytosolic phospholipase A2endothelial cellsNFκB

Identifiers

PMID30399318
PMCPMC8091167
OpenAlexW2899688047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.