ArticleNucleic acids research2019
InterPro in 2019: improving coverage, classification and access to protein sequence annotations.
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Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 856 papers, 1 of them a synthesis that pooled it.
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856citing papers in PubMed, 1 pooled it
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856 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- PDBe-SIFTS: an open-source tool for Structure Integration with Function, Taxonomy, and Sequences, featuring improved alignment, scoring scheme, and accelerated search.bioRxiv : the preprint server for biology · 2026Article
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796 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors.
Alex L MitchellEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Teresa K AttwoodSchool of Computer Science, The University of Manchester, Manchester M13 9PL, UK.
Patricia C BabbittDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.
Matthias BlumEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Peer BorkEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr.1, 69117 Heidelberg, Germany.
Alan BridgeSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Shoshana D BrownDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.
Hsin-Yu ChangEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Sara El-GebaliEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Matthew I FraserEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Julian GoughMedical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
David R HaftJ. Craig Venter Institute (JCVI), 9605 Medical Center Drive, Suite 150, Rockville, MD 20850, USA.
Hongzhan HuangCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA.
Ivica LetunicBiobyte Solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.
Rodrigo LopezEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Aurélien LucianiEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Fabio MadeiraEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Aron Marchler-BauerNational Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Huaiyu MiDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Darren A NataleProtein Information Resource, Georgetown University Medical Center, Washington, DC, USA.
Marco NecciDepartment of Biomedical Sciences, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
Gift NukaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Christine OrengoStructural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
Arun P PanduranganMedical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Typhaine Paysan-LafosseEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Sebastien PesseatEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Simon C PotterEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Matloob A QureshiEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Neil D RawlingsEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Nicole RedaschiSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Lorna J RichardsonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Catherine RivoireSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Gustavo A SalazarEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Amaia Sangrador-VegasEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Christian J A SigristSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Ian SillitoeStructural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
Granger G SuttonJ. Craig Venter Institute (JCVI), 9605 Medical Center Drive, Suite 150, Rockville, MD 20850, USA.
Narmada ThankiNational Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Paul D ThomasDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
Siew-Yit YongEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Robert D FinnEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Funding
National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7MResource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7MBiotechnology and Biological Sciences Research Council BB/L024136/1Biotechnology and Biological Sciences Research Council BB/N00521X/1Biotechnology and Biological Sciences Research Council BB/N019172/1Medical Research Council MC_UP_1201/14NHGRI NIH HHS U41 HG002273Wellcome Trust
Abstract
The InterPro database (http://www.ebi.ac.uk/interpro/) classifies protein sequences into families and predicts the presence of functionally important domains and sites. Here, we report recent developments with InterPro (version 70.0) and its associated software, including an 18% growth in the size of the database in terms on new InterPro entries, updates to content, the inclusion of an additional entry type, refined modelling of discontinuous domains, and the development of a new programmatic interface and website. These developments extend and enrich the information provided by InterPro, and provide greater flexibility in terms of data access. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB, and discuss how our evaluation of residue coverage may help guide future curation activities.
Indexed as
Databases, ProteinMolecular Sequence AnnotationAnimalsDatabases, GeneticGene OntologyHumansInternetMultigene FamilyProtein DomainsSequence Homology, Amino AcidSoftwareUser-Computer Interface
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