ArticleInvestigative ophthalmology & visual science2018
Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Differences of the lamina cribrosa between primary open angle glaucoma and non-pathologic high myopia.International journal of ophthalmology · 2026Review
- Comparing corneal biomechanical parameters between primary open-angle glaucoma and pseudoexfoliation glaucoma using corvis ST.BMC ophthalmology · 2025Article
- Changes in Choroidal Thickness and Its Effects on the Refractive Outcome After Surgical Treatment of Cataract Using Phacoemulsification Combined With Goniosynechialysis in Patients With Primary Angle Closure/Glaucoma.Journal of ophthalmology · 2025Article
- Comparison of intraocular pressure fluctuation and glaucoma progression rate between phakic and pseudophakic eyes in pseudoexfoliation glaucoma.Scientific reports · 2024Article
- A comprehensive enhanced depth imaging spectral-domain optical coherence tomography analysis of pseudoexfoliation spectrum from non-glaucomatous to advanced stage glaucoma in the aspect of Bruch's membrane opening-minimum rim width.International ophthalmology · 2022Article
- Effect of pseudoexfoliation syndrome on lamina cribrosa morphology after uneventful phacoemulsification.International ophthalmology · 2022Article
- Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrews.Biomedical optics express · 2022Article
- Optic nerve head vessel density in different stages of pseudoexfoliation disease.The British journal of ophthalmology · 2022Article
- Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects.Scientific reports · 2021Article
- Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa.Scientific reports · 2021Article
- Does Pseudoexfoliation Syndrome Affect the Choroidal Response After Uneventful Phacoemulsification.Investigative ophthalmology & visual science · 2020Article
- EDI-OCT choroidal thickness in Posner-Schlossman syndrome.International ophthalmology · 2020Observational
- Relationship of Corneal Hysteresis and Anterior Lamina Cribrosa Displacement in Glaucoma.American journal of ophthalmology · 2020Observational
- Bruch's membrane opening enlargement and its implication on the myopic optic nerve head.Scientific reports · 2019Article
- Choroidal Vascularity Index Alterations across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes.Journal of current ophthalmologyArticle
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Purpose: To better understand the relationship of lamina cribrosa (LC) and choroid features to the severity of pseudoexfoliation glaucoma (PXG). Methods: In this cross-sectional study, 137 eyes of 122 subjects (47 eyes with moderate/advanced PXG [mean deviation (MD), -15.0 ± 7.7 dB], 34 eyes with mild PXG [MD, -2.7 ± 1.5 dB], 32 aged-matched pseudoexfoliation syndrome [PXS] eyes, and 24 aged-matched control eyes) were investigated. Optic discs, LC thickness, and anterior LC depth (ALD; midsuperior, center, and midinferior) as well as peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust for age, sex, and axial length. Results: A progressive decrease in LC thickness was found when comparing controls (271.9 ± 61.3 μm), PXS (212.6 ± 51.5 μm), mild PXG (180.8 ± 24.6 μm), and moderate/advance PXG (138.9 ± 37.5 μm) (P < 0.001). ALD was greater (P < 0.001) in moderate/advance glaucoma (306.7 ± 105.3 μm) and mild PXG (209.5 ± 79.7 μm) compared with PXS (155 ± 86.7 μm) and healthy controls (149.2 ± 103 μm). Although eyes with moderate/advance PXG had the thinnest choroid (117.2 ± 36.6 μm), choroidal thickness was comparable in mild PXG, PXS, and controls (150.0 ± 46.1, 159.7 ± 65.5, and 157.5 ± 51.1 μm, respectively; P = 0.002). Worse MD was the only factor associated with thinner LC (β = 2.344, P < 0.001) and choroid (β = 1.717, P = 0.009 μm) in PXG eyes. Higher IOP (β = 4.305, P = 0.013) and worse MD (β = -6.390, P < 0.001) were associated with deeper ALD in PXG. Conclusions: In pseudoexfoliation, LC thinning is an early sign, and there is progressive thinning with advancing glaucoma. Choroidal thinning is observable only with moderate/advanced glaucoma. In PXG eyes, LC thickness, depth, and peripapillary choroidal thickness are associated with glaucoma severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.