Evidence map›Paper›PMID 30398387›Full record

ArticleTissue engineering. Part A2019

Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation.

Madison A P McGough, Stefanie M Shiels, Lauren A Boller, Katarzyna J Zienkiewicz, Craig L Duvall, Joseph C Wenke, Scott A Guelcher

Abstract read
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Biomimetic Polyurethanes in Tissue Engineering.Biomimetics (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madison A P McGough1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Stefanie M Shiels3U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas.
Lauren A Boller1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Katarzyna J Zienkiewicz4Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee.
Craig L Duvall1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Joseph C Wenke3U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas.
Scott A Guelcher1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.

Funding

Substrate Mediated siRNA Delivery from Scaffolds to Promote Wound RepairR01EB019409 · NIBIB · VANDERBILT UNIVERSITY · PI Craig Lewis Duvall · 2014 to 2026
$4.0M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
Biofilm Dispersive Bone Grafts to Improve Healing of Contaminated FracturesR01AR064772 · NIAMS · VANDERBILT UNIVERSITY · PI GUELCHER, SCOTT A, WENKE, JOSEPH C · 2014 to 2018
$1.8M
NIAMS NIH HHS R01 AR064772NIBIB NIH HHS R01 EB019409NIDDK NIH HHS T32 DK101003
6 · The paper itself

Abstract

impact statementThe development of autograft extenders is a significant clinical need in bone tissue engineering. We report new settable poly(thioketal urethane)-based autograft extenders that have bone-like mechanical properties and handling properties comparable to calcium phosphate bone cements. These settable autograft extenders remodeled to form new bone in a biologically stringent intertransverse process model of bone formation that does not heal when treated with calcium phosphate bone void fillers or cements alone. This is the first study to report settable autograft extenders with bone-like strength and handling properties comparable to ceramic bone cements, which have the potential to improve treatment of bone fractures and other orthopedic conditions.

Indexed as

Models, BiologicalAnimalsAutograftsBone TransplantationCalcium PhosphatesCatalysisCell LineMiceOsteogenesisPolyurethanesRabbitsRats, NudeSheepX-Ray Microtomographycalcium phosphateCalcium Phosphatespoly(thioketal urethane)Polyurethanesautograft extenderbonepolyurethanerabbitthioketal

Identifiers

PMID30398387
PMCPMC6648232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.