ArticleThe American journal of tropical medicine and hygiene2019
Handheld Point-of-Care Lactate Measurement at Admission Predicts Mortality in Ugandan Children Hospitalized with Pneumonia: A Prospective Cohort Study.
Article in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review.Journal of global health · 2023Pooled it
- Prevalence of hypoxaemia in children with pneumonia in low-income and middle-income countries: a systematic review and meta-analysis.The Lancet. Global health · 2022Pooled it
- The effects of mobile health on emergency care in low- and middle-income countries: A systematic review and narrative synthesis.Journal of global health · 2021Pooled it
- Trial
- Advanced biomarkers for prognostic evaluation of pneumonia severity in pediatric intensive care: focus on novel inflammatory and hematological ratios.Italian journal of pediatrics · 2025Article
- A cross-sectional study of point-of-care lactate testing in integrated community care management (ICCM) for children with acute respiratory illness in rural uganda.International health · 2025Article
- Long-term impact of 10-valent pneumococcal conjugate vaccine among children <5 years, Uganda, 2014-2021.PLOS global public health · 2025Article
- Heparin-Binding Protein Stratifies Mortality Risk Among Ugandan Children Hospitalized With Respiratory Distress.Open forum infectious diseases · 2024Article
- Pediatric Malaria with Respiratory Distress: Prognostic Significance of Point-of-Care Lactate.Microorganisms · 2023Article
- Prognostic accuracy of biomarkers of immune and endothelial activation in Mozambican children hospitalized with pneumonia.PLOS global public health · 2023Article
- Serum Lactate and Mortality during Pediatric Admissions: Is 2 Really the Magic Number?Journal of pediatric intensive care · 2022Review
- Relationship Between Lactate Levels and Length of Hospital Stay in Infants with Lower Respiratory Tract Infection.Pediatric allergy, immunology, and pulmonology · 2021Article
- Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam.Global pediatric health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, pneumonia is the leading cause of death among children younger than 5 years old, with most deaths occurring in low-income countries. Rapid bedside tools to assist practitioners to accurately triage and risk-stratify these patients may improve clinical care and patient outcomes. We conducted a prospective cohort study of children with pneumonia admitted to two Ugandan hospitals to examine the predictive value of a single point-of-care lactate measurement using a commercially available handheld device, the Lactate Scout Analyzer. One hundred and fifty-five children were included, 90 (58%) male, with a median (interquartile range [IQR]) age of 11 (1.4-20) months. One hundred and twenty-five (81%) patients had chest indrawing, 133 (86%) were hypoxemic, and 75 (68%) had a chest x-ray abnormality. In-hospital mortality was 22/155 (14%). Median (IQR) admission lactate level was 2.4 (1.8-3.6) mmol/L among children who survived versus 7.2 (2.6-9.7) mmol/L among those who died (
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