Evidence map›Paper›PMID 30397975›Full record

ReviewCell proliferation2019

Recent progress in the emerging role of exosome in hepatocellular carcinoma.

Mubalake Abudoureyimu, Hao Zhou, Yingru Zhi, Ting Wang, Bing Feng, Rui Wang, Xiaoyuan Chu

Open access · hybridAbstract readReview
In one paragraph

Review in Cell proliferation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance.Journal of cellular and molecular medicine · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. The Role of Extracellular Vesicles in Liver Pathogenesis.The American journal of pathology · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Exosomal microRNAs in hepatocellular carcinoma.Cancer cell international · 2021
    Review
  20. Dairy consumption and hepatocellular carcinoma risk.Annals of translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mubalake AbudoureyimuDepartment of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0001-6012-6463
Hao ZhouDepartment of Medical Oncology, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Yingru ZhiDepartment of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-9389-6058
Ting WangDepartment of Medical Oncology, Jinling Hospital, Nanjing, China.
Bing FengDepartment of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
Rui WangDepartment of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
Xiaoyuan ChuDepartment of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
Nanjing General Hospital of Nanjing Military Command · CN

Funding

Excellent Youth Foundation of Jiangsu Province BK20140032National Natural Science Foundation of China 81472266National Natural Science Foundation of China 81772995
6 · The paper itself

Abstract

Exosomes are small membrane vesicles 50-150 nm in diameter released by a variety of cells, which contain miRNAs, mRNAs and proteins with the potential to regulate signalling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to participate in orchestrating cell-cell communication and microenvironment modulation. In this review, we summarize recent progress in our understanding of the role of exosomes in hepatocellular carcinoma (HCC). This review focuses on recent studies on HCC exosomes, considering biogenesis, cargo and their effects on the development and progression of HCC, including chemoresistance, epithelial-mesenchymal transition, angiogenesis, metastasis and immune response. Finally, we discuss the clinical application of exosomes as a therapeutic agent for HCC.

Indexed as

AnimalsCarcinogenesisCarcinoma, HepatocellularDisease ProgressionEpithelial-Mesenchymal TransitionExosomesHumansImmunityLiverLiver NeoplasmsTumor Microenvironmentcarcinogenesisexosomeshepatocellular carcinomatumour microenvironment

Identifiers

PMID30397975
PMCPMC6496614
OpenAlexW2900429954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.