ArticleJournal of gastrointestinal cancer2019
Radio-pathological Correlation of 18F-FDG PET in Characterizing Gallbladder Wall Thickening.
Article in Journal of gastrointestinal cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Early detection of gallbladder cancer: Current status and future perspectives.World journal of clinical oncology · 2025Review
- Update on the Role of Imaging in the Diagnosis, Staging, and Prognostication of Gallbladder Cancer.The Indian journal of radiology & imaging · 2025Review
- Dynamic growth risk of incidentally detected gallbladder polyps-A retrospective, single-center analysis.PloS one · 2025Article
- Hepato-pancreato-biliary tuberculosis: A review.Turkish journal of surgery · 2024Review
- Multiparameter diagnostic model based onBMC cancer · 2023Article
- Gallbladder polyps and adenomyomatosis.The British journal of radiology · 2023Review
- Imaging patterns of wall thickening type of gallbladder cancer.Clinical and experimental hepatology · 2022Review
- Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.European radiology · 2022Article
- Asymptomatic chronic suppurative cholecystitis and peritonitis mimicking metastasis byBJR case reports · 2022Article
- Carcinosarcoma of gallbladder: A world review.World journal of clinical oncology · 2021Article
- Imaging-based algorithmic approach to gallbladder wall thickening.World journal of gastroenterology · 2020Review
- Navigating the Diagnostic Dilemma of Evaluating Gallbladder Wall Thickening: Are We There Yet?Journal of clinical and experimental hepatologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThick-walled gallbladder is difficult to characterize on conventional imaging. 18F-FDG PET was used to differentiate benign and malignant wall thickness and compared with histopathology.
methodsThirty patients with gallbladder (GB) wall thickening (focal > 4 mm and diffuse > 7 mm), underwents uspected on ultrasound, or CT scan, and underwent 18F-FDG PET. Histopathology of the specimen was compared with imaging findings.
resultsThe mean age was 48.22 ± 31.33 years with a M:F 1:4 ratio. Twenty patients had diffuse and 10 had focal thickening. On 18F-FDG PET, lesion was benign in 12, malignant in 13, and indeterminate in 5. Histopathology was malignancy in 12; benign in 18-chronic cholecystitis in 11, xanthogranulomatous in 4, IgG4 related in 2, and polyp in 1. The mean GB wall thickness was 7.79 ± 3.59 mm (10.34 malignant and 6.10 in benign, p = 0.001). At a cutoff of 8.5 mm, the sensitivity and specificity of detecting malignancy was 94% and 67%. The mean SUV uptake was 7.46 (benign 4.51, malignant 14.26, p = 0.0102). At a cutoff of 5.95, the sensitivity and specificity of detecting malignancy was 92% and 79%. For 18F-FDG PET, overall sensitivity was 91%, specificity 79%, PPV 77%, NPV 92%, and diagnostic accuracy was 84%.
conclusion18F-FDG PET is a reliable method of differentiation between benign and malignant thickening of the gallbladder particularly when wall thickness and SUV value is taken into account.
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