Evidence map›Paper›PMID 30397855›Full record

ArticleIn vitro cellular & developmental biology. Animal2019

Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E

Kazuhiro Nagayama, Yoichi Miyamoto, Kotaro Kaneko, Kentaro Yoshimura, Kiyohito Sasa, Takaaki Akaike, Shigemoto Fujii, Eri Izumida, Risa Uyama, Daichi Chikazu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Role of nitric oxide in orthodontic tooth movement (Review).International journal of molecular medicine · 2021
    Review
  2. Article
  3. Journal of clinical biochemistry and nutrition · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kazuhiro NagayamaDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Yoichi MiyamotoDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan. yoichim@dent.showa-u.ac.jp.
Kotaro KanekoDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Kentaro YoshimuraDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Kiyohito SasaDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Takaaki AkaikeDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shigemoto FujiiDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Eri IzumidaDepartment of Orthodontics, Showa University School of Dentistry, Shinagawa, Japan.
Risa UyamaDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Daichi ChikazuDepartment of Oral and Maxillofacial Surgery, Tokyo Medical University, Shinjuku, Japan.
Koutaro MakiDepartment of Orthodontics, Showa University School of Dentistry, Shinagawa, Japan.
Ryutaro KamijoDepartment of Biochemistry, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Showa University · JPTohoku University · JPTokyo Medical University · JP

Funding

Japan Society for the Promotion of Science 15H05016Japan Society for the Promotion of Science 15K11053Ministry of Education, Culture, Sports, Science and Technology S1411009
6 · The paper itself

Abstract

Osteocytes regulate bone remodeling, especially in response to mechanical loading and unloading of bone, with nitric oxide reported to play an important role in that process. In the present study, we found that 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), a second messenger of nitric oxide in various types of cells, was produced by osteocytes in bone tissue as well as cultured osteocytic Ocy454 cells. The amount of 8-nitro-cGMP in Ocy454 cells increased during incubation with parathyroid hormone or prostaglandin E

Indexed as

Up-RegulationAdaptor Proteins, Signal TransducingAnimalsCell LineCyclic GMPDinoprostoneExtracellular Matrix ProteinsFemurGlycoproteinsIntercellular Signaling Peptides and ProteinsMaleMice, Inbred C57BLOsteocytesOsteoprotegerinParathyroid HormoneRANK Ligand8-nitroguanosine 3',5'-cyclic monophosphateAdaptor Proteins, Signal TransducingCyclic GMPDinoprostoneDmp1 protein, mouseExtracellular Matrix ProteinsGlycoproteinsIntercellular Signaling Peptides and ProteinsOsteoprotegerinParathyroid HormoneRANK LigandRNA, MessengerSost protein, mouseTumor Necrosis Factor-alpha8-Nitro-cGMPNitric oxideOsteocytesParathyroid hormone

Identifiers

PMID30397855
OpenAlexW2900001875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.