Evidence map›Paper›PMID 30397825›Full record

ArticleJournal of neurovirology2019

Vibrio vulnificus meningoencephalitis in a patient with thalassemia and a splenectomy.

Rongni He, Wenxia Zheng, Jun Long, Yaowei Huang, Cuiping Liu, Qing Wang, Zhenxing Yan, Huayong Liu, Li Xing, Yafang Hu and 1 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Microorganisms · 2025
    Review
  4. Review
  5. Healthy adults withThe Journal of international medical research · 2022
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rongni HeDepartment of Neurology, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China.
Wenxia ZhengDepartment of Neurology, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China.
Jun LongDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China.
Yaowei HuangThe First School of Clinical Medicine, Southern Medical University, 1808 North Guanghzou Ave, Guangzhou, 510515, Guangdong, China.
Cuiping LiuIntensive Care Unit, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China.
Qing WangDepartment of Neurology, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China.
Zhenxing YanDepartment of Neurology, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China.
Huayong LiuBinhai Genomics Institute, BGI-Shenzhen, Shenzhen, 518083, China.
Li XingBinhai Genomics Institute, BGI-Shenzhen, Shenzhen, 518083, China.
Yafang HuDepartment of Neurology, Nanfang Hospital, Southern Medical University, 1808 North Guanghzou Ave., Guangzhou, 510515, Guangdong, China. yafanghu@smu.edu.cn.
Huifang XieDepartment of Neurology, Zhujiang Hospital, Southern Medical University, 253 Middle Industrial Avenue, Guangzhou, 510282, Guangdong, China. xhffhx@126.com.
Southern Medical University · CNZhujiang Hospital · CNBGI Group (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vibrio vulnificus usually causes wound infection, gastroenteritis, and septicemia. However, it is a rare conditional pathogen causing meningoencephalitis. We report a case of a young, immunocompromised man presenting with severe sepsis after exposure to sea water and consumption of seafood. The patient subsequently developed meningoencephalitis, and Vibrio vulnificus was isolated from his blood culture. The sequence was confirmed by Next-generation sequencing of a sample of cerebrospinal fluid, as well as from a bacteria culture. After the pathogen was detected, the patient was treated with ceftriaxone, doxycycline, and moxifloxacin for 6 weeks, which controlled his infection. In this case, we acquired his clinical and dynamic MRI presentations, which were never reported. Physicians should consider Vibrio vulnificus infections when they see a similar clinical course, brain CT and MRI findings, susceptibility factors and recent seafood ingestion or exposure to seawater. Due to high mortality, the early diagnosis and treatment of Vibrio vulnificus infections are crucial. Next-generation sequencing was found to be useful for diagnosis.

Indexed as

Immunocompromised HostAdultAnti-Bacterial AgentsCeftriaxoneDoxycyclineHumansMagnetic Resonance ImagingMaleMeningoencephalitisMoxifloxacinSeafoodSeawaterSepsisSplenectomyThalassemiaTreatment OutcomeAnti-Bacterial AgentsCeftriaxoneDoxycyclineMoxifloxacinClinical manifestationsMRI presentationsNext-generation sequencingVibrio vulnificus meningoencephalitis

Identifiers

PMID30397825
OpenAlexW2899594547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.