ArticleBMJ paediatrics open2018
High body mass index in children with sickle cell disease: a retrospective single-centre audit.
Article in BMJ paediatrics open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04676113 (Obesity in Pediatric Sickle Cell Disease), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Obesity in Pediatric Sickle Cell Disease: A New Phenomenon
Who cites it
7 citing papers in PubMed.
- EHA Guidelines on the management of children and adults with hemoglobin SC disease.HemaSphere · 2026Article
- Hemoglobin S Promotes Glycemic Dysregulation in a Mouse Model of Human Sickle Cell Disease.Endocrinology · 2025Article
- International variations in body mass index within the CASiRe global cohort of sickle cell disease patients.Journal of sickle cell disease · 2025Article
- Characterising the prevalence of overweight and obese status among adults with sickle cell disease.British journal of haematology · 2023Article
- Adiponectin and Disease Severity in Sickle Cell Anemia Patients Attending a Tertiary Health Institution in Nnewi, Southeast Nigeria.Frontiers in genetics · 2022Article
- Response to Letter to the Editor: Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004-2014.Obesity surgery · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the prevalence of high body mass index (BMI) in children with sickle cell disease and assess correlation between BMI and disease severity.
designRetrospective chart review followed by statistical analysis.
settingA single tertiary paediatric clinic in inner city London. PATIENTS: All patients with sickle cell disease, including homozygous haemoglobin (HbSS) and compound heterozygous Hb (HbSC), age 2-18 years receiving clinical care at the centre, were included in the study.
interventionsHeight and weight measurements, steady-state laboratory blood tests, hospital admission rates, adjunct therapy such as hydroxycarbamide or blood transfusions and obstructive sleep apnoea (OSA) data were obtained from the hospital electronic patient records.
main outcome measuresTo study the prevalence of high BMI and to identify any correlation between BMI and disease severity.
results385 patients were included. 64 children (17%) were overweight or obese, of which a significantly higher number of children with HbSC were obese or overweight (23 out of 91, 25%) compared with those with HbSS (36 out of 273, 13%), p≤0.001. No correlation was found between high BMI and presence of OSA, and markers of disease severity such as admission rates, fetal haemoglobin or lactate dehydrogenase levels.
conclusionsHigh BMI did not correlate with disease severity in this cohort of patients with sickle cell disease. Obesity was more prevalent in females and those with HbSC. Further prospective studies are needed to determine long-term effects of BMI in disease severity and outcome.
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