ArticleScience advances2018
Cell chirality regulates intercellular junctions and endothelial permeability.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed.
- Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.APL bioengineering · 2026Review
- Fluid Forces Control Structural Remodeling of Blind-Ended Lymphatic Microvessels.Advanced healthcare materials · 2026Article
- Human Endothelial Membrane as a Structural Prototype: A Comparative Analysis withInternational journal of molecular sciences · 2026Article
- Contractile forces direct the chiral swirling of minimal cell collectives.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pro-Angiogenic Bioactive Molecules in Vascular Morphogenesis: Integrating Endothelial Cell Dynamics.Current issues in molecular biology · 2025Review
- Psoriasis: A Multidimensional Review of Onset, Progression, Treatment, and the Evolution of Disease Models.Molecular diagnosis & therapy · 2025Review
- Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Use of a new micropattern tape method to detect chirality shifts in differentiating C2C12 cells.PloS one · 2025Article
- Acute COVID-19 and LongCOVID syndrome - molecular implications for therapeutic strategies - review.Frontiers in immunology · 2025Review
- Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.bioRxiv : the preprint server for biology · 2024Article
- Cell Chirality of Micropatterned Endometrial Microvascular Endothelial Cells.Advanced healthcare materials · 2024Article
- Biomechanical Modeling of Cell Chirality and Symmetry Breaking of Biological Systems.Mechanobiology in medicine · 2024Article
- Asymmetrical positioning of cell organelles reflects the cell chirality of mouse myoblast cells.APL bioengineering · 2024Article
- Helical vasculogenesis driven by cell chirality.Science advances · 2024Article
- Advances in Regulating Cellular Behavior Using Micropatterns.The Yale journal of biology and medicine · 2023Review
- Construction of chiral capillary electrochromatography microsystems based on Aspergillus sp. CM96.Mikrochimica acta · 2023Article
- The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases.Heliyon · 2023Review
- The Actin Crosslinker Fascin Regulates Cell Chirality.Advanced biology · 2023Article
- Interacting with tumor cells weakens the intrinsic clockwise chirality of endothelial cells.APL bioengineering · 2022Article
- Cell chirality exhibition of brain microvascular endothelial cells is dependent on micropattern width.RSC advances · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell to polarize in the left-right axis. Despite increasing evidence on its substantial role in the asymmetric development of embryos, little is known about implications of cell chirality in physiology and disease. We demonstrate that cell chirality accounts for the nonmonotonic, dose-response relationship between endothelial permeability and protein kinase C (PKC) activation. The permeability of the endothelial cell layer is tightly controlled in our body, and dysregulation often leads to tissue inflammation and diseases. Our results show that low-level PKC activation is sufficient to reverse cell chirality through phosphatidylinositol 3-kinase/AKT signaling and alters junctional protein organization between cells with opposite chirality, leading to an unexpected substantial change in endothelial permeability. Our findings suggest that cell chirality regulates intercellular junctions in important ways, providing new opportunities for drug delivery across tightly connected semipermeable cellular sheets.
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