Evidence map›Paper›PMID 30397597›Full record

ArticleMolecular neuropsychiatry2018

Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.

Josine E Verhoeven, Ruoting Yang, Owen M Wolkowitz, Francesco S Bersani, Daniel Lindqvist, Synthia H Mellon, Rachel Yehuda, Janine D Flory, Jue Lin, Duna Abu-Amara and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neuropsychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. DNA methylation GrimAge acceleration in US military veterans with PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  8. Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Josine E VerhoevenDepartment of Psychiatry, UCSF Weill Institute for Neuroscience, University of California San Francisco, School of Medicine, San Francisco, California, USA.
Ruoting YangD, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Owen M WolkowitzDepartment of Psychiatry, UCSF Weill Institute for Neuroscience, University of California San Francisco, School of Medicine, San Francisco, California, USA.
Francesco S BersaniDepartment of Psychiatry, UCSF Weill Institute for Neuroscience, University of California San Francisco, School of Medicine, San Francisco, California, USA.
Daniel LindqvistDepartment of Psychiatry, UCSF Weill Institute for Neuroscience, University of California San Francisco, School of Medicine, San Francisco, California, USA.
Synthia H MellonDepartment of OB/GYN and Reproductive Sciences, University of California San Francisco, School of Medicine, San Francisco, California, USA.
Rachel YehudaJames J. Peters Veterans Administration Medical Center Bronx, New York, New York, USA.
Janine D FloryJames J. Peters Veterans Administration Medical Center Bronx, New York, New York, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California San Francisco, School of Medicine, San Francisco, California, USA.
Duna Abu-AmaraSteven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, New York, New York, USA.
Iouri MakotkineJames J. Peters Veterans Administration Medical Center Bronx, New York, New York, USA.
Charles MarmarSteven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, New York, New York, USA.
Marti JettIntegrative Systems Biology, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.
Rasha HammamiehIntegrative Systems Biology, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.
University of California, San Francisco · USCenter for Environmental Health · USJames J. Peters VA Medical Center · USCohen Children's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation patterns change with age and can be used to derive an estimate of "epigenetic age," an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variables in 160 male combat-exposed war veterans with (

Indexed as

AgingAntidepressantsEpigeneticsPosttraumatic stress disorder

Identifiers

PMID30397597
PMCPMC6206951
OpenAlexW2891777363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.