ArticleMolecular neuropsychiatry2018
Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder.
Article in Molecular neuropsychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.Molecular psychiatry · 2021Pooled it
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2023Article
- Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans.Journal of Alzheimer's disease : JAD · 2023Article
- Regional associations of white matter integrity and neurological, post-traumatic stress disorder and autonomic symptoms in Veterans with and without history of loss of consciousness in mild TBI.Frontiers in neuroimaging · 2023Article
- Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder.Psychiatry investigation · 2022Article
- Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.Biological psychiatry · 2022Review
- Asymmetric alterations of white matter integrity in patients with insomnia disorder.Brain imaging and behavior · 2022Article
- White matter diffusivity and its correlations to state measures of psychopathology in male refugees with posttraumatic stress disorder.NeuroImage. Clinical · 2022Article
- Acute White Matter Integrity Post-trauma and Prospective Posttraumatic Stress Disorder Symptoms.Frontiers in human neuroscience · 2021Article
- Current and future functional imaging techniques for post-traumatic stress disorder.RSC advances · 2019Review
- Traumatic Brain Injury and Posttraumatic Stress Disorder: Comorbid Consequences of War.Neuroscience insights · 2019Review
- Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)Article
- Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of the studyPrior studies showed posttraumatic stress disorder (PTSD)-related alterations in white matter integrity, but most of these studies have used region-based approaches. We address this limitation by investigating the relationship between PTSD severity and fractional anisotropy (FA) using a tract-based approach. PROCEDURES: Structural and diffusion magnetic resonance imaging were acquired from 67 combat-exposed US Veterans and processed using FSL/FreeSurfer TRActs Constrained by UnderLying Anatomy. Partial correlations were conducted between PTSD severity and FA of the cingulum and uncinate fasciculi covarying for age, sex, and head motion.
resultsOnly FA of the left cingulum angular bundle (CAB) was positively correlated with PTSD symptom severity (
conclusionsThis finding may imply greater organization of the CAB with increasing PTSD severity. The CAB connects directly to the cingulate cortex and the hippocampal subiculum, critical nodes of the default mode network, as well as being implicated in neurodegeneration pathology, decision-making, and executive functions, which may help explain previously shown alterations in this network in PTSD. MESSAGE OF THE PAPER: Further study of white matter tract integrity in PTSD is warranted, particularly to investigate whether the CAB connections with both higher-order cognitive functioning and emotion processing regions contribute to the pathophysiology and comorbidity of PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.