ArticleThe mental health clinician2018
Major depressive disorder in children and adolescents.
Article in The mental health clinician, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Brief CBT-based psychological interventions to improve mental health outcomes in refugee populations: a systematic review and meta-analysis.European journal of psychotraumatology · 2024Pooled it
- Transcranial magnetic stimulation in the treatment of adolescent depression: a systematic review and meta-analysis of aggregated and individual-patient data from uncontrolled studies.European child & adolescent psychiatry · 2022Pooled it
- Immune response to vaccination in adults with mental disorders: A systematic review.Journal of affective disorders · 2022Pooled it
- A systematic review of the latent structure of the Center for Epidemiologic Studies Depression Scale (CES-D) amongst adolescents.BMC psychiatry · 2021Pooled it
- Exploring fatigue in clinically depressed adolescents: a secondary analysis of the IMPACT study sample.BMC psychology · 2026Trial
- Vortioxetine in children and adolescents with major depressive disorder: 6-month and 18-month open-label, flexible-dose, long-term extension studies.European child & adolescent psychiatry · 2025Trial
- The experience of cognitive behavioural therapy in depressed adolescents who are fatigued.Psychology and psychotherapy · 2022Trial
- Impact of a Secondary School Depression Prevention Curriculum on Adolescent Social-Emotional Skills: Evaluation of the Resilient Families Program.Journal of youth and adolescence · 2019Trial
- Reciprocal changes in electrophysiological and behavioral metrics reflecting empathy impairment among adolescents with major depressive disorder.BMC psychiatry · 2026Article
- Examining Longitudinal, Reciprocal Relations Between Mental Health Service Use and Mental Health Symptoms.The journal of behavioral health services & research · 2026Article
- Cross-Platform and cross-species lipidomic profiling identifies promising biomarkers for adolescent major depressive disorder.Molecular psychiatry · 2026Article
- The Longitudinal Interplay Between Loneliness and Depressive Symptoms During Late Childhood: Cross-Lagged Panel Network Analyses.European journal of investigation in health, psychology and education · 2026Article
- Urinary copper is linked to regional cortical volume reductions in adolescents with major depressive disorder.Translational psychiatry · 2026Article
- Review
- Role of Mast Cells and Neuroinflammation in Neuropsychiatric Disorders of the Developmental Period.Biomolecules · 2026Review
- The validity and reliability of the Patient Health Questionnaire - Adolescent version (PHQ - A) in Vietnam.BMC psychology · 2026Article
- Optimal exercise prescription for depression and anxiety in children and adolescents: a Bayesian dose-response network meta-analysis protocol.Systematic reviews · 2026Article
- Efficacy and Safety of Escitalopram for Major Depressive Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis with Age-Specific Findings.Neuropsychiatric disease and treatment · 2026Review
- Screen time, physical activity, sleep, and depression risk in adolescents: an observational study based on the compositional isotemporal substitution model.Frontiers in public health · 2026Observational
- Prevalence and psychosocial correlates of depressive symptom risk among secondary school students in Saudi Arabia: a mixed-methods study.Frontiers in child and adolescent psychiatry · 2026Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
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Abstract
Major depressive disorder (MDD) is one of the most common psychiatric disorders of childhood and adolescence, but because of symptom variation from the adult criteria, it is often unrecognized and untreated. Symptom severity predicts the initial mode of treatment ranging from psychotherapy to medications to combination treatment. Several studies have assessed the efficacy of treatment in children and adolescents, and others have evaluated the risk of developing adverse effects and/or new or worsening suicidal thoughts and behaviors. Optimal treatment often includes a combination of therapy and antidepressant medication. The most studied combination includes fluoxetine with cognitive behavioral therapy. Once symptom remission is obtained, treatment should be continued for 6 to 12 months before a slow taper is initiated. Although most children and adolescents recover from their first depressive episode, a large number will continue to present with MDD in adulthood. Untreated depression in children and adolescents may increase the risk of substance abuse; poor work, academic, and social functioning; and risk of suicidal behaviors.
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