Evidence map›Paper›PMID 30397357›Full record

ArticleNature medicine2018

Expanded skin virome in DOCK8-deficient patients.

Osnat Tirosh, Sean Conlan, Clay Deming, Shih-Queen Lee-Lin, Xin Huang, NISC Comparative Sequencing Program, Helen C Su, Alexandra F Freeman, Julia A Segre, Heidi H Kong

Open access · bronzeAbstract read
In one paragraph

Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. The potential impacts of human genetics on virus emergence.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. The human skin microbiome in health.Journal of the American Academy of Dermatology · 2025
    Review
  14. Article
  15. Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Osnat TiroshTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Sean ConlanTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Clay DemingTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Shih-Queen Lee-LinTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Xin HuangTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
NISC Comparative Sequencing Program
Helen C SuLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Julia A SegreTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA. jsegre@nhgri.nih.gov.ORCID http://orcid.org/0000-0001-6860-348X
Heidi H KongCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. konghe@mail.nih.gov.ORCID http://orcid.org/0000-0003-4424-064X
National Human Genome Research Institute · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

Inter- and Intra-Species Comparative SequencingZIBHG000196 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI THOMAS, JAMES · 2009 to 2025
$177.6M
Gene-Environment Interactions at the Skin SurfaceZIAHG000180 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SEGRE, JULIA ANGELA · 2009 to 2025
$29.6M
Primary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7M
Effects of systemic and topical perturbations on human microbesZIABC011558 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2014 to 2021
$6.9M
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIABC010938 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2009 to 2021
$5.4M
Understanding DOCK8 Function in Health and Human DiseaseZIAAI001193 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2014 to 2025
$4.5M
Transcriptional Regulation of Epidermal DifferentiationZ01HG000180 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SEGRE, JULIA ANGELA · 2001 to 2008
$2.4M
Intramural NIH HHS Z01 HG000180Intramural NIH HHS ZIA AI001193Intramural NIH HHS ZIA BC010938
6 · The paper itself

Abstract

Human microbiome studies have revealed the intricate interplay of host immunity and bacterial communities to achieve homeostatic balance. Healthy skin microbial communities are dominated by bacteria with low viral representation

Indexed as

AdolescentBacteriophagesChildFemaleGenome, ViralGuanine Nucleotide Exchange FactorsHealthy VolunteersHost Microbial InteractionsHumansImmunityImmunologic Deficiency SyndromesLymphocytesMaleMetagenomeMicrobiotaPapillomaviridaeDOCK8 protein, humanGuanine Nucleotide Exchange Factors

Identifiers

PMID30397357
PMCPMC6286253
OpenAlexW2898307788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.