Evidence map›Paper›PMID 30397344›Full record

ArticleNature microbiology2018

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model.

Kazuyuki Kasahara, Kimberly A Krautkramer, Elin Org, Kymberleigh A Romano, Robert L Kerby, Eugenio I Vivas, Margarete Mehrabian, John M Denu, Fredrik Bäckhed, Aldons J Lusis and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 287 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
287citing papers in PubMed, 3 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

287 citing papers in PubMed, 3 syntheses or guidelines pooled it, 541 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

227 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Kazuyuki KasaharaDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Kimberly A KrautkramerWisconsin Institute for Discovery, Madison, WI, USA.
Elin OrgDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Kymberleigh A RomanoDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Robert L KerbyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Eugenio I VivasDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Margarete MehrabianDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
John M DenuWisconsin Institute for Discovery, Madison, WI, USA.
Fredrik BäckhedWallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Aldons J LusisDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Federico E ReyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. ferey@wisc.edu.ORCID http://orcid.org/0000-0002-0239-7780
University of Wisconsin–Madison · USUniversity of California, Los Angeles · USUniversity of Gothenburg · SE

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
TRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2M
Molecular mechanisms of histone modification - Alzheimer’s supplement NOT-AG-18-008R37GM059785 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M · 2013 to 2022
$3.7M
Collaborative Cross of the Microbiome and Metabolic DiseaseR01DK108259 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REY, FEDERICO E · 2015 to 2019
$2.1M
Interactions between gut microbial metabolism and host epigenomeF30DK108494 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI KRAUTKRAMER, KIMBERLY ANN · 2016 to 2018
$93k
NHLBI NIH HHS P01 HL030568NIDDK NIH HHS F30 DK108494NIDDK NIH HHS R01 DK108259NIDDK NIH HHS T32 DK007665NIGMS NIH HHS R37 GM059785NIGMS NIH HHS T32 GM008692
6 · The paper itself

Abstract

Humans with metabolic and inflammatory diseases frequently harbour lower levels of butyrate-producing bacteria in their gut. However, it is not known whether variation in the levels of these organisms is causally linked with disease development and whether diet modifies the impact of these bacteria on health. Here we show that a prominent gut-associated butyrate-producing bacterial genus (Roseburia) is inversely correlated with atherosclerotic lesion development in a genetically diverse mouse population. We use germ-free apolipoprotein E-deficient mice colonized with synthetic microbial communities that differ in their capacity to generate butyrate to demonstrate that Roseburia intestinalis interacts with dietary plant polysaccharides to: impact gene expression in the intestine, directing metabolism away from glycolysis and toward fatty acid utilization; lower systemic inflammation; and ameliorate atherosclerosis. Furthermore, intestinal administration of butyrate reduces endotoxaemia and atherosclerosis development. Together, our results illustrate how modifiable diet-by-microbiota interactions impact cardiovascular disease, and suggest that interventions aimed at increasing the representation of butyrate-producing bacteria may provide protection against atherosclerosis.

Indexed as

AtherosclerosisDietGastrointestinal MicrobiomeAnimalsApolipoproteins EButyratesCardiovascular DiseasesColonDietary CarbohydratesDisease Models, AnimalEndotoxemiaEnergy MetabolismEubacterialesFatty AcidsFecesGene ExpressionApolipoproteins EButyratesDietary CarbohydratesFatty AcidsRNA, Ribosomal, 16S

Identifiers

PMID30397344
PMCPMC6280189
OpenAlexW2898905022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.