ArticleNature genetics2018
Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia.
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Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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29 citing papers in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
58 authors.
Haihua Bai *School of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
Xiaosen Guo *BGI-Shenzhen, Shenzhen, China.
Narisu Narisu *Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8483-1156
Tianming Lan *BGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0002-6934-0439
Qizhu Wu *Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.
Yanping XingCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Yong ZhangBGI-Shenzhen, Shenzhen, China.
Stephen R BondComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Zhili PeiCollege of Computer Science and Technology, Inner Mongolia University for the Nationalities, Tongliao, China.
Yanru ZhangCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Dandan ZhangBGI-Shenzhen, Shenzhen, China.
Jirimutu JirimutuCollege of Mathematics, Inner Mongolia University for the Nationalities, Tongliao, China.
Dong ZhangCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Xukui YangBGI Genomics, BGI-Shenzhen, Shenzhen, China.
Morigenbatu MorigenbatuCollege of Mongolian Studies, Inner Mongolia University for the Nationalities, Tongliao, China.
Li ZhangCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Bingyi DingBGI-Shenzhen, Shenzhen, China.
Baozhu GuanInner Mongolia International Mongolian Hospital, Hohhot, China.
Junwei CaoCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Haorong LuBGI-Shenzhen, Shenzhen, China.
Yiyi LiuCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Wangsheng LiBGI-Shenzhen, Shenzhen, China.
Ningxin DangBGI-Shenzhen, Shenzhen, China.
Mingyang JiangCollege of Computer Science and Technology, Inner Mongolia University for the Nationalities, Tongliao, China.
Shenyuan WangCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Huixin XuBGI-Shenzhen, Shenzhen, China.
Dingzhu WangCollege of Mongolian Studies, Inner Mongolia University for the Nationalities, Tongliao, China.
Chunxia LiuCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Xin LuoBGI-Shenzhen, Shenzhen, China.
Ying GaoSchool of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
Xueqiong LiCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.ORCID http://orcid.org/0000-0002-1736-5183
Zongze WuLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Liqing YangAffiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.
Fanhua MengCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Xiaolian NingBGI-Shenzhen, Shenzhen, China.
Hashenqimuge HashenqimugeAffiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.
Kaifeng WuCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Bo WangBGI-Shenzhen, Shenzhen, China.
Suyalatu SuyalatuSchool of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
Yingchun LiuCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Chen YeBGI-Shenzhen, Shenzhen, China.
Huiguang WuSchool of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
Kalle LeppäläBioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Lu LiCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Lin FangBGI-Shenzhen, Shenzhen, China.
Yujie ChenSchool of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
Wenhao XuBGI-Shenzhen, Shenzhen, China.
Tao LiCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
Xin LiuBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0003-3256-2940
Xun XuBGI-Shenzhen, Shenzhen, China.
Christopher R GignouxColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Huanming YangBGI-Shenzhen, Shenzhen, China.
Lawrence C BrodyGene and Environment Interaction Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jun WangBGI-Shenzhen, Shenzhen, China.
Karsten KristiansenBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0002-6024-0917
Burenbatu BurenbatuAffiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China. brbt2013@163.com.
Huanmin ZhouCollege of Life Science, Inner Mongolia Agricultural University, Hohhot, China. huanminzhou@263.net.
Ye YinLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark. yinye@genomics.cn.ORCID http://orcid.org/0000-0002-7051-1987
Funding
The contribution folate and vitamin B12 genes to disease.ZIAHG000167 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BRODY, LAWRENCE C · 2009 to 2025
$17.6MNIH HHS 4U01HG007419-04
Abstract
The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.
Indexed as
Genetics, PopulationAmericasAsia, EasternAsia, NorthernAsian PeopleEuropeFemaleGene FlowGenome, HumanHumansMaleMongoliaPhylogenyWhole Genome Sequencing
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