ArticleNature materials2019
Solving mazes with single-molecule DNA navigators.
Article in Nature materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed.
- ATP-fueled autonomous pathway-selective signal transduction on DNA-nanostructure tracks.Nature communications · 2026Article
- A general and scalable DNA nano-chip with a fully localized architecture enables biocomputing in living cells and precisely induces cell apoptosis.Chemical science · 2026Article
- Reset-free DNA logic circuits for real-time input processing and memory.Science advances · 2026Article
- crRNA scaffold remodeling controls CRISPR-Cas12a activity for enhanced performance.Nucleic acids research · 2026Article
- Translating Nature's Design Rules: How Catalysis and Life Science Guide Molecular Catassembly.JACS Au · 2026Review
- Expanding DNA alphabet adds a previously unknown dimension to nanostructures.Science advances · 2026Article
- Linked data storage using DNA origami nanostructures.Nature communications · 2025Article
- Designing a DNA synchronizer for compact single-rail DNA logic circuits.Science advances · 2025Article
- A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface.International journal of molecular sciences · 2025Article
- Synthetic transmembrane DNA receptors enable engineered sensing and actuation.Nature communications · 2025Article
- Instruction-responsive programmable assemblies with DNA origami block pieces.Nucleic acids research · 2025Article
- Artificial molecular communication network based on DNA nanostructures recognition.Nature communications · 2025Article
- High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register.ACS central science · 2024Article
- Multicellular artificial neural network-type architectures demonstrate computational problem solving.Nature chemical biology · 2024Article
- Encoding signal propagation on topology-programmed DNA origami.Nature chemistry · 2024Article
- Fluorescence-Based Multimodal DNA Logic Gates.Nanomaterials (Basel, Switzerland) · 2024Article
- The motive forces in DNA-enabled nanomachinery.iScience · 2024Review
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- A Patching and Coding Lipid Raft-Localized Universal Imaging Platform.Chemical & biomedical imaging · 2024Article
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Molecular devices with information-processing capabilities hold great promise for developing intelligent nanorobotics. Here we demonstrate a DNA navigator system that can perform single-molecule parallel depth-first search on a ten-vertex rooted tree defined on a two-dimensional DNA origami platform. Pathfinding by the DNA navigators exploits a localized strand exchange cascade, which is initiated at a unique trigger site on the origami with subsequent automatic progression along paths defined by DNA hairpins containing a universal traversal sequence. Each single-molecule navigator autonomously explores one of the possible paths through the tree. A specific solution path connecting a given pair of start and end vertices can then be easily extracted from the set of all paths taken by the navigators collectively. The solution path laid out on origami is illustrated with single-molecule imaging. Our approach points towards the realization of molecular materials with embedded computational functions operating at the single-molecule level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.