ArticleNature nanotechnology2018
Detection and identification of genetic material via single-molecule conductance.
Article in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 99 citations in OpenAlex.
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Developing design guidelines for controlling charge transport in DNA.Nature chemistry · 2026Article
- Article
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Sustainable Integration of Nanobiosensors in Biomedical and Civil Engineering: A Comprehensive Review.ACS omega · 2025Review
- Single-Molecule Electrical Conductance in Z-form DNA:RNA.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Molecular switching by proton-coupled electron transport drives giant negative differential resistance.Nature communications · 2024Article
- Electromigrated Gold Nanogap Tunnel Junction Arrays: Fabrication and Electrical Behavior in Liquid and Gaseous Media.ACS applied materials & interfaces · 2024Article
- Biosensors for Public Health and Environmental Monitoring: The Case for Sustainable Biosensing.ACS sustainable chemistry & engineering · 2024Review
- Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour.Chemical science · 2024Review
- Electronic Properties of DNA Origami Nanostructures Revealed byThe journal of physical chemistry. B · 2024Article
- Charge transport in individual short base stacked single-stranded RNA molecules.Scientific reports · 2023Article
- Electrical detection of RNA cancer biomarkers at the single-molecule level.Scientific reports · 2023Article
- Advances in single-molecule junctions as tools for chemical and biochemical analysis.Nature chemistry · 2023Review
- Charge Transport across Proteins inside Proteins: Tunneling across Encapsulin Protein Cages and the Effect of Cargo Proteins.Biomolecules · 2023Article
- Mapping DNA Conformations Using Single-Molecule Conductance Measurements.Biomolecules · 2023Article
- Charge transport properties of SARS-CoV-2 Delta variant (B.1.617.2).Process biochemistry (Barking, London, England) · 2022Article
- Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements.Biosensors · 2022Review
- Dynamic Interconversions of Single Molecules Probed by Recognition Tunneling at Cucurbit[7]uril-Functionalized Supramolecular Junctions.Angewandte Chemie (International ed. in English) · 2022Article
- A Chirality-Based Quantum Leap.ACS nano · 2022Review
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ongoing discoveries of RNA modalities (for example, non-coding, micro and enhancer) have resulted in an increased desire for detecting, sequencing and identifying RNA segments for applications in food safety, water and environmental protection, plant and animal pathology, clinical diagnosis and research, and bio-security. Here, we demonstrate that single-molecule conductance techniques can be used to extract biologically relevant information from short RNA oligonucleotides, that these measurements are sensitive to attomolar target concentrations, that they are capable of being multiplexed, and that they can detect targets of interest in the presence of other, possibly interfering, RNA sequences. We also demonstrate that the charge transport properties of RNA:DNA hybrids are sensitive to single-nucleotide polymorphisms, thus enabling differentiation between specific serotypes of Escherichia coli. Using a combination of spectroscopic and computational approaches, we determine that the conductance sensitivity primarily arises from the effects that the mutations have on the conformational structure of the molecules, rather than from the direct chemical substitutions. We believe that this approach can be further developed to make an electrically based sensor for diagnostic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.