ArticleScientific reports2018
EEG sharp waves are a biomarker of striatal neuronal survival after hypoxia-ischemia in preterm fetal sheep.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 35 citations in OpenAlex.
- Caffeine-augmented exercise as a pretreatment for locomotor and balance impairments induced by REM sleep deprivation in rats.Scientific reports · 2025Article
- Postoperative EEG abnormalities in relation to neurodevelopmental outcomes after pediatric cardiac surgery.Pediatric research · 2025Article
- Deep Learning for Generalized EEG Seizure Detection after Hypoxia-Ischemia-Preclinical Validation.Bioengineering (Basel, Switzerland) · 2024Article
- Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Postoperative hypernatremia is associated with worse brain injuries on EEG and MRI following pediatric cardiac surgery.Frontiers in cardiovascular medicine · 2023Article
- Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia.Frontiers in pediatrics · 2022Review
- Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep.International journal of molecular sciences · 2021Article
- The diagnostic value of ultrasound detection of the fetal middle cerebral artery, umbilical artery blood flow and fetal movement reduction in fetal distress.American journal of translational research · 2021Article
- Review
- Electroencephalogram studies of hypoxic ischemia in fetal and neonatal animal models.Neural regeneration research · 2020Review
- Latent Phase Identification of High-Frequency Micro-Scale Gamma Spike Transients in the Hypoxic Ischemic EEG of Preterm Fetal Sheep Using Spectral Analysis and Fuzzy Classifiers.Sensors (Basel, Switzerland) · 2020Article
- Applications of advanced signal processing and machine learning in the neonatal hypoxic-ischemic electroencephalogram.Neural regeneration research · 2020Article
- Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders.Frontiers in neurology · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The timing of hypoxia-ischemia (HI) in preterm infants is often uncertain and there are few biomarkers to determine whether infants are in a treatable stage of injury. We evaluated whether epileptiform sharp waves recorded from the parietal cortex could provide early prediction of neuronal loss after HI. Preterm fetal sheep (0.7 gestation) underwent acute HI induced by complete umbilical cord occlusion for 25 minutes (n = 6) or sham occlusion (control, n = 6). Neuronal survival was assessed 7 days after HI by immunohistochemistry. Sharp waves were quantified manually and using a wavelet-type-2-fuzzy-logic-system during the first 4 hours of recovery. HI resulted in significant subcortical neuronal loss. Sharp waves counted by the automated classifier in the first 30 minutes after HI were associated with greater neuronal survival in the caudate nucleus (r = 0.80), whereas sharp waves between 2-4 hours after HI were associated with reduced neuronal survival (r = -0.83). Manual and automated counts were closely correlated. This study suggests that automated quantification of sharp waves may be useful for early assessment of HI injury in preterm infants. However, the pattern of evolution of sharp waves after HI was markedly affected by the severity of neuronal loss, and therefore early, continuous monitoring is essential.
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