Evidence map›Paper›PMID 30397150›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.

Louise Y Fong, Ruiyan Jing, Karl J Smalley, Zi-Xuan Wang, Cristian Taccioli, Sili Fan, Hongping Chen, Hansjuerg Alder, Kay Huebner, John L Farber and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Abrogation of esophageal carcinoma development in miR-31 knockout rats.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Advances of Zinc Signaling Studies in Prostate Cancer.International journal of molecular sciences · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Louise Y FongDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107; louise.fong@jefferson.edu carlo.croce@osumc.edu.
Ruiyan JingDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.
Karl J SmalleySidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0003-1502-6759
Zi-Xuan WangDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.
Cristian TaccioliDepartment of Animal Medicine, Health and Production, University of Padova, 35122 Padova PD, Italy.
Sili FanNational Institutes of Health West Coast Metabolomics Center, University of California Davis Genome Center, University of California, Davis, CA 95616.
Hongping ChenSidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107.
Hansjuerg AlderDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.
Kay HuebnerDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.
John L FarberDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.
Oliver FiehnNational Institutes of Health West Coast Metabolomics Center, University of California Davis Genome Center, University of California, Davis, CA 95616.
Carlo M CroceDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210; louise.fong@jefferson.edu carlo.croce@osumc.edu.
Thomas Jefferson University · USThe Ohio State University · USNational Institutes of Health · USUniversity of Padua · IT

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
Cancer Gene Discovery to Identify Targetable TargetsR35CA197706 · NCI · OHIO STATE UNIVERSITY · PI CROCE, CARLO M · 2015 to 2021
$6.4M
Chemoprevention of upper aerodigestive tract cancer by dietary zincR01CA118560 · NCI · THOMAS JEFFERSON UNIVERSITY · PI FONG, LOUISE Y.Y. · 2006 to 2017
$2.7M
NCI NIH HHS R01 CA118560NCI NIH HHS R35 CA197706NIDDK NIH HHS U24 DK097154
6 · The paper itself

Abstract

Prostate cancer is a leading cause of cancer death in men over 50 years of age, and there is a characteristic marked decrease in Zn content in the malignant prostate cells. The cause and consequences of this loss have thus far been unknown. We found that in middle-aged rats a Zn-deficient diet reduces prostatic Zn levels (

Indexed as

AdenocarcinomaAnimalsCation Transport ProteinsCell ProliferationCitric AcidDietDisease Models, AnimalGene Expression Regulation, NeoplasticHumansMaleMicroRNAsProstateProstatic HyperplasiaProstatic NeoplasmsRatsRats, Sprague-DawleyCation Transport ProteinsCitric AcidMicroRNAsMIRN182 microRNA, ratMIRN183 microRNA, ratMIRN96 microRNA, ratSLC39A1 protein, ratZincdietary Zn intakeprostate cancer metabolic phenotypeprostate cancer riskuntargeted metabolomics profilinguntargeted miRNA profiling

Identifiers

PMID30397150
PMCPMC6255182
OpenAlexW2900107341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.