Evidence map›Paper›PMID 30397128›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Optimal molecular crowding accelerates group II intron folding and maximizes catalysis.

Bishnu P Paudel, Erica Fiorini, Richard Börner, Roland K O Sigel, David S Rueda

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Aggregation of Phosphates Enhances Enzyme Activity in Aqueous Solution.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
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  14. Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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  16. Review
  17. Cascade Kinetics in an Enzyme-Loaded Aqueous Two-Phase System.Langmuir : the ACS journal of surfaces and colloids · 2020
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  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Bishnu P PaudelMolecular Virology, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom.
Erica FioriniDepartment of Chemistry, University of Zurich, 8057 Zurich, Switzerland.
Richard BörnerDepartment of Chemistry, University of Zurich, 8057 Zurich, Switzerland.
Roland K O SigelDepartment of Chemistry, University of Zurich, 8057 Zurich, Switzerland roland.sigel@chem.uzh.ch david.rueda@imperial.ac.uk.
David S RuedaMolecular Virology, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom; roland.sigel@chem.uzh.ch david.rueda@imperial.ac.uk.ORCID 0000-0003-4657-6323
University of Zurich · CHImperial College London · GB

Funding

European Research Council 259092Medical Research Council MC-A658-5TY10Medical Research Council MC_UP_1102/5
6 · The paper itself

Abstract

Unlike in vivo conditions, group II intron ribozymes are known to require high magnesium(II) concentrations ([Mg

Indexed as

CatalysisCell BiologyComputational BiologyFluorescence Resonance Energy TransferIntracellular SpaceMagnesiumMolecular Dynamics SimulationNucleic Acid ConformationPolyethylene GlycolsProtein FoldingRNA, CatalyticRNA, Ribosomal, Self-SplicingD135 ribozyme, S cerevisiaeMagnesiumPolyethylene GlycolsRNA, CatalyticRNA, Ribosomal, Self-Splicingexcluded volume effectgroup II intron ribozymelarge-ribozyme foldingmolecular crowdingsingle-molecule FRET

Identifiers

PMID30397128
PMCPMC6255197
OpenAlexW2900270109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.