ArticleProceedings of the National Academy of Sciences of the United States of America2018
Face cells in orbitofrontal cortex represent social categories.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 66 citations in OpenAlex.
- Fast face-selective responses in prefrontal face patches of the macaque.Cell reports · 2025Article
- NSF Workshop Report: Exploring Measurements and Interpretations of Intelligent Behaviors Across Animal Model Systems.The Journal of comparative neurology · 2025Article
- Face pareidolia minimally engages macaque face selective neurons.Progress in neurobiology · 2025Article
- Prefrontal-Amygdala Pathways for Object and Social Value Representation.Journal of cognitive neuroscience · 2024Article
- Distributed network flows generate localized category selectivity in human visual cortex.PLoS computational biology · 2024Article
- Neuronal Mechanisms Underlying Face Recognition in Non-human Primates.The Japanese psychological research · 2024Article
- Simultaneous oscillatory encoding of "hot" and "cold" information during social interactions in the monkey medial prefrontal cortex.iScience · 2024Article
- Article
- Neuronal Population Encoding of Identity in Primate Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multisensory interactions of face and vocal information during perception and memory in ventrolateral prefrontal cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Probing the processing of facial expressions in monkeys via time perception and eye tracking.Zoological research · 2023Article
- Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala.Brain structure & function · 2023Review
- Toward reframing brain-social dynamics: current assumptions and future challenges.Frontiers in psychiatry · 2023Review
- Degenerate pathway for processing smile and other emotional expressions in congenital facial palsy: an hdEEG investigation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Oxytocin and testosterone administration amplify viewing preferences for sexual images in male rhesus macaques.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks.Neuron · 2022Article
- Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The neural correlates of context driven changes in the emotional response: An fMRI study.PloS one · 2022Article
- An Exploratory Analysis of the Neural Correlates of Human-Robot Interactions With Functional Near Infrared Spectroscopy.Frontiers in human neuroscience · 2022Article
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Perceiving social and emotional information from faces is a critical primate skill. For this purpose, primates evolved dedicated cortical architecture, especially in occipitotemporal areas, utilizing face-selective cells. Less understood face-selective neurons are present in the orbitofrontal cortex (OFC) and are our object of study. We examined 179 face-selective cells in the lateral sulcus of the OFC by characterizing their responses to a rich set of photographs of conspecific faces varying in age, gender, and facial expression. Principal component analysis and unsupervised cluster analysis of stimulus space both revealed that face cells encode face dimensions for social categories and emotions. Categories represented strongly were facial expressions (grin and threat versus lip smack), juvenile, and female monkeys. Cluster analyses of a control population of nearby cells lacking face selectivity did not categorize face stimuli in a meaningful way, suggesting that only face-selective cells directly support face categorization in OFC. Time course analyses of face cell activity from stimulus onset showed that faces were discriminated from nonfaces early, followed by within-face categorization for social and emotion content (i.e., young and facial expression). Face cells revealed no response to acoustic stimuli such as vocalizations and were poorly modulated by vocalizations added to faces. Neuronal responses remained stable when paired with positive or negative reinforcement, implying that face cells encode social information but not learned reward value associated to faces. Overall, our results shed light on a substantial role of the OFC in the characterizations of facial information bearing on social and emotional behavior.
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