Evidence map›Paper›PMID 30397058›Full record

ArticleAntimicrobial agents and chemotherapy2019

Effect of Moxifloxacin plus Pretomanid against

Carolina de Miranda Silva, Amirhossein Hajihosseini, Jenny Myrick, Jocelyn Nole, Arnold Louie, Stephan Schmidt, George L Drusano

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2019
    Guideline
  2. Article
  3. Article
  4. Delamanid or pretomanid? A Solomonic judgement!The Journal of antimicrobial chemotherapy · 2022
    Article
  5. Review
  6. Tools to develop antibiotic combinations that target drug tolerance inFrontiers in cellular and infection microbiology · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Perspectives for systems biology in the management of tuberculosis.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  11. Article
  12. Review
  13. Building Optimal Three-Drug Combination Chemotherapy Regimens.Antimicrobial agents and chemotherapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carolina de Miranda SilvaCenter for Pharmacometrics & Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Amirhossein HajihosseiniCenter for Pharmacometrics & Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Jenny MyrickInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Jocelyn NoleInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Arnold LouieInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Stephan SchmidtCenter for Pharmacometrics & Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA sschmidt@cop.ufl.edu.
George L DrusanoInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
University of Florida · USInstitute for Learning Innovation · US

Funding

Optimizing Combination Therapy to Accelerate Clinical Cure of TuberculosisP01AI123036 · NIAID · UNIVERSITY OF FLORIDA · PI FLYNN, JOANNE L. · 2016 to 2020
$12.0M
NIAID NIH HHS P01 AI123036
6 · The paper itself

Abstract

Combination therapy is a successful approach to treat tuberculosis in patients with susceptible strains of

Indexed as

Models, StatisticalAntitubercular AgentsDrug CombinationsDrug InteractionsDrug Resistance, FungalMicrobial Sensitivity TestsMoxifloxacinMycobacterium tuberculosisNitroimidazolesAntitubercular AgentsDrug CombinationsMoxifloxacinNitroimidazolespretomanidacid-phase-growth bacteriacombination therapylog-phase-growth bacteriamoxifloxacinMycobacterium tuberculosisnonreplicating-persister-phase-growth bacteriapretomanid

Identifiers

PMID30397058
PMCPMC6325209
OpenAlexW2900276565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.