Evidence map›Paper›PMID 30397057›Full record

ArticleAntimicrobial agents and chemotherapy2019

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.

Brian C Monk, Mikhail V Keniya, Manya Sabherwal, Rajni K Wilson, Danyon O Graham, Harith F Hassan, Danni Chen, Joel D A Tyndall

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Emerging Applications of Triazole Antifungal Drugs.International journal of molecular sciences · 2026
    Review
  5. The molecular basis of intrinsic resistance to azoles inAntimicrobial agents and chemotherapy · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. ExploringJournal of fungi (Basel, Switzerland) · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Characterisation ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  18. Antifungal Resistance and the Role of New Therapeutic Agents.Current infectious disease reports · 2022
    Review
  19. Structural Insights into the Azole Resistance of theJournal of fungi (Basel, Switzerland) · 2021
    Article
  20. Design, Synthesis, andACS omega · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brian C MonkSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand brian.monk@otago.ac.nz.
Mikhail V KeniyaSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Manya SabherwalSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Rajni K WilsonSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Danyon O GrahamSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Harith F HassanSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Danni ChenSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Joel D A TyndallSchool of Pharmacy, University of Otago, Dunedin, New Zealand.
University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of

Indexed as

Amino Acid SequenceAntifungal AgentsATP-Binding Cassette TransportersCandida albicansCandida glabrataCatalytic DomainCloning, MolecularCrystallography, X-RayDrug Resistance, FungalFungal ProteinsGene ExpressionGenetic VectorsMicrobial Sensitivity TestsModels, MolecularMutationProtein BindingAntifungal AgentsATP-Binding Cassette TransportersFungal ProteinsposaconazolePyridinesRecombinant Fusion ProteinsSterol 14-DemethylaseTetrazolesTriazolesVT-1161antifungal resistanceCandida albicansCandida glabratacrystal structureCYP51fungal infectionsposaconazoleSaccharomyces cerevisiaetetrazole inhibitorVT-1161

Identifiers

PMID30397057
PMCPMC6325177
OpenAlexW2899681054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.