Evidence map›Paper›PMID 30397012›Full record

ArticleThe Journal of general physiology2019

The tarantula toxin GxTx detains K

Drew C Tilley, Juan M Angueyra, Kenneth S Eum, Heesoo Kim, Luke H Chao, Anthony W Peng, Jon T Sack

Abstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Neuronomodulation of Excitable Neurons.Neuroscience bulletin · 2024
    Review
  5. The formation of KCommunications biology · 2023
    Article
  6. The formation of KResearch square · 2023
    Article
  7. Mechanism of use-dependent Kv2 channel inhibition by RY785.The Journal of general physiology · 2022
    Article
  8. Article
  9. Article
  10. AFrontiers in pharmacology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Peptide Toxins Targeting KV Channels.Handbook of experimental pharmacology · 2021
    Review
  15. Review
  16. Variation of Two S3b Residues in KFrontiers in pharmacology · 2021
    Article
  17. Article
  18. Kv2.1 channels play opposing roles in regulating membrane potential, CaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Unlocking the gating mechanism of Kv2.1 using guangxitoxin.The Journal of general physiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Drew C TilleyDepartment of Physiology & Membrane Biology, University of California, Davis, Davis, CA.ORCID 0000-0002-5616-2661
Juan M AngueyraNeurobiology Course, Marine Biological Laboratory, Woods Hole, MA.ORCID 0000-0002-9217-3069
Kenneth S EumDepartment of Physiology & Membrane Biology, University of California, Davis, Davis, CA.
Heesoo KimNeurobiology Course, Marine Biological Laboratory, Woods Hole, MA.
Luke H ChaoNeurobiology Course, Marine Biological Laboratory, Woods Hole, MA.ORCID 0000-0002-4849-4148
Anthony W PengNeurobiology Course, Marine Biological Laboratory, Woods Hole, MA.ORCID 0000-0002-2208-6779
Jon T SackDepartment of Physiology & Membrane Biology, University of California, Davis, Davis, CA jsack@ucdavis.edu.ORCID 0000-0002-6975-982X

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Neurobiology Summer CourseR25NS063307 · NINDS · MARINE BIOLOGICAL LABORATORY · PI Ricardo C Araneda, Michael Blake Hoppa · 2008 to 2026
$3.5M
Genetically Encoded Reporters of Integrated Neural Activity for Functional Mapping of Neural Circuitry-Administrative SupplementU01NS090581 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LAM, KIT S, TRIMMER, JAMES S · 2014 to 2016
$2.2M
Visualizing endogenous ion channel activationR01NS096317 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COHEN, BRUCE E, SACK, JON THOMAS · 2016 to 2019
$1.4M
Neuronal voltage tracers for photoacoustic imaging in the deep brainR21EY026449 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SACK, JON THOMAS · 2015 to 2016
$459k
NEI NIH HHS R21 EY026449NHLBI NIH HHS T32 HL086350NINDS NIH HHS R01 NS096317NINDS NIH HHS R25 NS063307NINDS NIH HHS U01 NS090581
6 · The paper itself

Abstract

Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand-protein complexes. Here we investigate how ligand binding to a K

Indexed as

Ion Channel GatingAllosteric RegulationAllosteric SiteAnimalsArthropod ProteinsCHO CellsCricetinaeCricetulusProtein BindingRatsShab Potassium ChannelsSpider VenomsArthropod ProteinsGxTX-1E, Plesiophrictus guangxiensisKcnb1 protein, ratShab Potassium ChannelsSpider Venoms

Identifiers

PMID30397012
PMCPMC6400525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.