Evidence map›Paper›PMID 30396999›Full record

ArticleThe Journal of cell biology2019

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.

Nathaniel Noblett, Zilu Wu, Zhao Hua Ding, Seungmee Park, Tony Roenspies, Stephane Flibotte, Andrew D Chisholm, Yishi Jin, Antonio Colavita

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  6. Transcriptomic profiling ofComputational and structural biotechnology journal · 2024
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  19. DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth.Frontiers in cellular neuroscience · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nathaniel NoblettNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Zilu WuSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA.
Zhao Hua DingNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Seungmee ParkSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA.ORCID 0000-0001-8718-4057
Tony RoenspiesNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Stephane FlibotteDepartment of Zoology, University of British Columbia, Vancouver, Canada.
Andrew D ChisholmSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA.ORCID 0000-0001-5091-0537
Yishi JinSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA yijin@ucsd.edu.ORCID 0000-0002-9371-9860
Antonio ColavitaNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Canada acolavita@ohri.ca.ORCID 0000-0001-9391-5282
University of California San Diego · USUniversity of Ottawa · CAOttawa Hospital · CAUniversity of British Columbia · CA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Cytoskeletal dynamics in axon regenerationR01NS093588 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHISHOLM, ANDREW D, JIN, YISHI · 2015 to 2023
$3.7M
NIH HHS P40 OD010440NINDS NIH HHS R01 NS093588
6 · The paper itself

Abstract

Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal development, the mechanisms that maintain mature neuronal structures and architecture are little understood. The conserved disco-interacting protein 2 (DIP2) consists of a DMAP1-binding domain and two adenylate-forming domains (AFDs). We show that the

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCytoskeletal ProteinsGene Expression Regulation, DevelopmentalLarvaMAP Kinase Kinase KinasesMutationNerve RegenerationNeuronal OutgrowthNeuronal PlasticityNeuronsNuclear ProteinsProtein Interaction Domains and MotifsSignal TransductionCaenorhabditis elegans ProteinsCytoskeletal Proteinsdip-2 protein, C elegansDLK-1 protein, C elegansEFA-6 protein, C elegansMAP Kinase Kinase KinasesNuclear Proteins

Identifiers

PMID30396999
PMCPMC6314549
OpenAlexW2903632839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.