Evidence map›Paper›PMID 30396922›Full record

ArticleAnticancer research2018

Cystathione β-Synthase Is Increased in Thyroid Malignancies.

Elba A Turbat-Herrera, Matthew J Kilpatrick, Jie Chen, Andrew T Meram, James Cotelingam, Ghali Ghali, Christopher G Kevil, Domenico Coppola, Rodney E Shackelford

Abstract read
In one paragraph

Article in Anticancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Significance of GSH and HRedox report : communications in free radical research · 2026
    Review
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  3. Article
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  7. Article
  8. Review
  9. The putative role of gut microbiota in cancer: Cysteine is a pivotal coin.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022
    Review
  10. Article
  11. Hydrogen Sulfide Suppresses Skin Fibroblast ProliferationOxidative medicine and cellular longevity · 2022
    Article
  12. CystathionineOxidative medicine and cellular longevity · 2022
    Article
  13. Article
  14. Molecular Functions of Hydrogen Sulfide in Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
  15. Article
  16. The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Role of Hydrogen Sulfide in the Endocrine System.Frontiers in endocrinology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elba A Turbat-HerreraDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Matthew J KilpatrickDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Jie ChenDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Andrew T MeramHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
James CotelingamDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Ghali GhaliHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Christopher G KevilDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Domenico CoppolaDepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.
Rodney E ShackelfordDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. rshack@lsuhsc.edu.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundCystathione β-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H MATERIALS AND

methodsThis study employed tissue microarrays to examine CBS expression in benign thyroid tissue, thyroid oncocytomas, thyroid follicular adenomas, and in follicular, papillary, anaplastic, and medullary thyroid carcinomas.

resultsCBS expression was increased in all thyroid carcinomas types compared to benign thyroid tissue, but not in thyroid follicular adenomas or oncocytomas. A similar pattern was observed for nicotinamide phosphoribosyltransferase (NAMPT) tissue microarray analysis comparing thyroid adenomas and follicular carcinomas.

conclusionFor the first time, we showed that an H

Indexed as

Adenocarcinoma, FollicularAdenoma, OxyphilicCarcinoma, NeuroendocrineCystathionine beta-SynthaseCytokinesHumansHydrogen SulfideImmunohistochemistryNicotinamide PhosphoribosyltransferaseThyroid Cancer, PapillaryThyroid Carcinoma, AnaplasticThyroid NeoplasmsTissue Array AnalysisCystathionine beta-SynthaseCytokinesHydrogen SulfideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanCystathione β-synthasefollicular adenomafollicular carcinomaNAMPTthyroid

Identifiers

PMID30396922
PMCPMC7771238

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.