Evidence map›Paper›PMID 30396897›Full record

ArticleInfection and immunity2019

Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1-Dependent Manner.

Mingyu Hou, Wenhui Wang, Feizi Hu, Yuanxing Zhang, Dahai Yang, Qin Liu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mingyu HouState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Wenhui WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Feizi HuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Yuanxing ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Dahai YangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Qin LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China qinliu@ecust.edu.cn.
East China University of Science and Technology · CNMarine Design & Research Institute of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial phosphothreonine lyases have been identified to be type III secretion system (T3SS) effectors that irreversibly dephosphorylate host mitogen-activated protein kinase (MAPK) signaling to promote infection. However, the effects of phosphothreonine lyase on nuclear factor κB (NF-κB) signaling remain largely unknown. In this study, we detected significant phosphothreonine lyase-dependent p65 degradation during

Indexed as

Host-Pathogen InteractionsAnimalsCarbon-Oxygen LyasesCell LineEdwardsiellaeIF-2 KinaseEnterobacteriaceae InfectionsMacrophagesMiceMitogen-Activated Protein Kinase 8ProteolysisCarbon-Oxygen LyaseseIF-2 KinaseMitogen-Activated Protein Kinase 8phosphothreonine lyase, Salmonella entericaMAPKsMSK1p65 degradationphosphothreonine lyase

Identifiers

PMID30396897
PMCPMC6300619
OpenAlexW2900395656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.