ArticleJournal of clinical research in pediatric endocrinology2019
Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children
Article in Journal of clinical research in pediatric endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- French national diagnosis and care protocol (PNDS) for infantile idiopathic hypercalcemia (IIH).Orphanet journal of rare diseases · 2026Review
- A 3-Year-Old Child With Incidental High-Dose Vitamin D Intoxication: A Case Report and Literature Review.Case reports in endocrinology · 2025Article
- Successful Management of Severe Hypercalcemia with Zoledronic Acid: A Report of Two Pediatric CasesJournal of clinical research in pediatric endocrinology · 2024Article
- Life-threatening hypercalcemia in a child with vitamin D intoxication due to parental self-medication: A case report.SAGE open medical case reports · 2024Article
- Vitamin D status among residents of Molidawa Daur Autonomous Banner, Inner Mongolia, North China.Saudi medical journal · 2023Article
- Genetic Forms of Calciopenic Rickets.The Eurasian journal of medicine · 2022Article
- Everything in excess is opposed to nature, even vitamin D: a case report.Endocrinology, diabetes & metabolism case reports · 2022Article
- An Infant with Asymptomatic Vitamin D Intoxication: A Prolonged and Sustainable Recovery.Case reports in endocrinology · 2022Article
- Vitamin D Toxicity Managed with Peritoneal Dialysis.Case reports in endocrinology · 2021Article
- Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia.Northern clinics of Istanbul · 2020Article
- Vitamin D Intoxication Presenting as Subacute Encephalopathy-A Case Report.Child neurology openArticle
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Authors and funding
17 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate as first-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospective study assessing clinical characteristics and treatment results. Methods: A standard questionnaire was uploaded to an online national database system to collect data on children with hypercalcemia (serum calcium level >10.5 mg/dL) due to vitamin D intoxication [serum 25-hydroxyvitamin D (25(OH)D) level >150 ng/mL] who were treated in pediatric endocrinology clinics. Results: Seventy-four children [median (range) age 1.06 (0.65-1.60) years, 45 males (61%) from 11 centers] were included. High-dose vitamin D intake was evident in 77% of the cases. At diagnosis, serum calcium, phosphorus, alkaline phosphatase, 25(OH)D and parathyroid hormone concentrations were 15±3.2 mg/dL, 5.2±1.2 mg/dL, 268±132 IU/L, 322 (236-454) ng/mL, and 5.5 (3-10.5) pg/mL, respectively. Calcium levels showed moderate correlation with 25(OH)D levels (r Conclusion: Prednisolone is less effective in the treatment of children with severe hypercalcaemia secondary to vitamin D intoxication and timely implementation of other treatment regimens should be considered.
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