Evidence map›Paper›PMID 30396335›Full record

SynthesisBMC neurology2018

Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies.

Chi-Hsien Huang, Chi-Wei Lin, Yi-Che Lee, Chih-Yuan Huang, Ru-Yi Huang, Yi-Cheng Tai, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun, Hao-Kuang Wang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  5. Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I-a randomized, placebo-controlled, double-blind, Asian-Pacific trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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  18. Resistance and Resilience to Alzheimer's Disease.Cold Spring Harbor perspectives in medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chi-Hsien HuangDepartment of Family Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chi-Wei LinDepartment of Family Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Yi-Che LeeSchool of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
Chih-Yuan HuangNeurosurgical Service, Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.
Ru-Yi HuangDepartment of Family Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Yi-Cheng TaiDepartment of Neurology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Kuo-Wei WangSchool of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
San-Nan YangSchool of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
Yuan-Ting SunDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hao-Kuang WangSchool of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan. ed101393@gmail.com.ORCID http://orcid.org/0000-0002-1928-7502
E-Da Hospital · TWI-Shou University · TWNational Cheng Kung University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the association of prior traumatic brain injury (TBI) with subsequent diagnosis of neurodegeneration disease.

methodsAll studies from 1980 to 2016 reporting TBI as a risk factor for diagnoses of interest were identified by searching PubMed, Embase, study references, and review articles. The data and study design were assessed by 2 investigators independently. A meta-analysis was performed by RevMan 5.3.

resultsThere were 18 studies comprising 3,263,207 patients. Meta-analysis revealed a significant association of prior TBI with subsequent dementia. The pooled odds ratio (OR) for TBI on development of dementia, FTD and TDP-43 associated disease were 1.93 (95% CI 1.47-2.55, p < 0.001), 4.44 (95% CI 3.86-5.10, p < 0.001), and 2.97 (95% CI 1.35-6.53, p < 0.001). However, analyses of individual diagnoses found no evidence that the risk of Alzheimer's disease, and Parkinson's disease in individuals with previous TBI compared to those without TBI.

conclusionsHistory of TBI is not associated with the development of subsequent neurodegeneration disease. Care must be taken in extrapolating from these results because no suitable criteria define post TBI neurodegenerative processes. Therefore, further research in this area is needed to confirm these questions and uncover the link between TBI and neurodegeneration disease.

Indexed as

Brain Injuries, TraumaticFemaleHumansNeurodegenerative DiseasesOdds RatioResearch DesignRisk FactorsYoung AdultDementiaMeta-analysisNeurodegenerationTBI

Identifiers

PMID30396335
PMCPMC6217762
OpenAlexW2899543462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.