Evidence map›Paper›PMID 30396259›Full record

ArticleInternational neurourology journal2018

New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders.

Syed M Q Hussaini, Mi Hyeon Jang

Open access · diamondAbstract read
In one paragraph

Article in International neurourology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. The Neuroimmunology of Autism.Molecular neurobiology · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Emerging roles of N-linked glycosylation in brain physiology and disorders.Trends in endocrinology and metabolism: TEM · 2021
    Review
  10. Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex.The international journal of neuropsychopharmacology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Reactive Glia Inflammatory Signaling Pathways and Epilepsy.International journal of molecular sciences · 2020
    Review
  16. Astrocyte Senescence and Alzheimer's Disease: A Review.Frontiers in aging neuroscience · 2020
    Review
  17. Article
  18. Review
  19. Article
  20. How to Interpret the Effects Shown in Animal Study.International neurourology journal · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Syed M Q HussainiDepartment of Internal Medicine, Duke University Medical Center, Durham, NC, USA.
Mi Hyeon JangDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Duke Medical Center · USMayo Clinic · US

Funding

Role of BubR1 as a juvenile protective factor in hippocampal agingR01AG058560 · NIA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI JANG, MI-HYEON · 2018 to 2022
$2.3M
National Institute on Aging R01AG058560NIA NIH HHS R01 AG058560
6 · The paper itself

Abstract

Previously believed to solely play a supportive role in the central nervous system, astrocytes are now considered active players in normal brain function. Evidence in recent decades extends their contributions beyond the classically held brain glue role; it's now known that astrocytes act as a unique excitable component with functions extending into local network modulation, synaptic plasticity, and memory formation, and postinjury repair. In this review article, we highlight our growing understanding of astrocyte function and physiology, the increasing role of gliotransmitters in neuron-glia communication, and the role of astrocytes in modulating synaptic plasticity and cognitive function. Owing to the duality of both beneficial and deleterious roles attributed to astrocytes, we also discuss the implications of this new knowledge as it applies to neurological disorders including Alzheimer disease, epilepsy, and schizophrenia.

Indexed as

AstrocyteCentral nervous systemNeurological disordersSynaptic plasticity

Identifiers

PMID30396259
PMCPMC6234728
OpenAlexW2899453291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.