ArticlePLoS pathogens2018
Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 119 citations in OpenAlex.
- Integrated Histological, Ultrastructural, Lectin and Immunohistochemical Characterization of the Senegalese sole (Animals : an open access journal from MDPI · 2026Article
- p53 regulates early mucosal immunity via antigen presentation in zebrafish intestine post-SVCV vaccination.Cell communication and signaling : CCS · 2026Article
- Comparative Transcriptomics of Olfactory Rosettes Reveals Expression Divergence and Adaptive Evolution in Herbivorous and Carnivorous Xenocyprididae Fishes.Animals : an open access journal from MDPI · 2025Article
- Newly discovered and conserved role of IgM against viral infection in an early vertebrate.eLife · 2025Article
- Host-Microbiota-Parasite Interactions in Grass Carp: Insights fromMicroorganisms · 2025Article
- Immunoglobulin M response in largemouth bass (Frontiers in immunology · 2025Article
- Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus.PLoS pathogens · 2024Article
- Duration of Protection and Humoral Immune Response in Nile Tilapia (Animals : an open access journal from MDPI · 2024Article
- Olfactory immunology: the missing piece in airway and CNS defence.Nature reviews. Immunology · 2024Review
- Mucosal immune responses toMarine life science & technology · 2024Article
- Distinct distribution and responses of IgMFrontiers in immunology · 2024Article
- An Introduction to Relevant Immunology Principles with Respect to Oral Vaccines in Aquaculture.Microorganisms · 2023Review
- Monoclonal antibody generated against Nile tilapia (Fish and shellfish immunology reports · 2023Article
- The Distribution of IgT mRNAAnimals : an open access journal from MDPI · 2023Article
- Expression analysis of Igs and mucosal immune responses upon SVCV infection in common carp (Fish and shellfish immunology reports · 2022Article
- Mucosal plasma cells are required to protect the upper airway and brain from infection.Immunity · 2022Article
- Review
- Severe Natural Outbreak ofInternational journal of molecular sciences · 2022Article
- The Olfactory Organ Is a Unique Site for Neutrophils in the Brain.Frontiers in immunology · 2022Article
- Pro-inflammatory cytokine responses toFrontiers in tropical diseases · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory organ of vertebrates receives chemical cues present in the air or water and, at the same time, they are exposed to invading pathogens. Nasal-associated lymphoid tissue (NALT), which serves as a mucosal inductive site for humoral immune responses against antigen stimulation in mammals, is present also in teleosts. IgT in teleosts is responsible for similar functions to those carried out by IgA in mammals. Moreover, teleost NALT is known to contain B-cells and teleost nasal mucus contains immunoglobulins (Igs). Yet, whether nasal B cells and Igs respond to infection remains unknown. We hypothesized that water-borne parasites can invade the nasal cavity of fish and elicit local specific immune responses. To address this hypothesis, we developed a model of bath infection with the Ichthyophthirius multifiliis (Ich) parasite in rainbow trout, Oncorhynchus mykiss, an ancient bony fish, and investigated the nasal adaptive immune response against this parasite. Critically, we found that Ich parasites in water could reach the nasal cavity and successfully invade the nasal mucosa. Moreover, strong parasite-specific IgT responses were detected in the nasal mucus, and the accumulation of IgT+ B-cells was noted in the nasal epidermis after Ich infection. Strikingly, local IgT+ B-cell proliferation and parasite-specific IgT generation were found in the trout olfactory organ, providing new evidence that nasal-specific immune responses were induced locally by a parasitic challenge. Overall, our findings suggest that nasal mucosal adaptive immune responses are similar to those reported in other fish mucosal sites and that an antibody system with a dedicated mucosal Ig performs evolutionary conserved functions across vertebrate mucosal surfaces.
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