ArticlePloS one2018
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Air pollution: a latent key driving force of dementia.BMC public health · 2024Pooled it
- PMiScience · 2026Review
- Air Pollution Exposure, Prefrontal Connectivity, and Emotional Behavior in Early Adolescence.Research report (Health Effects Institute) · 2025Article
- The Epidemiological and Toxicological Intersection of Air Pollution and Dementia.Reviews of environmental contamination and toxicology · 2025Review
- Erratum: "Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model".Environmental health perspectives · 2024Article
- Effect of Air Pollution Particulate Matter on Ischemic and Hemorrhagic Stroke: A Scoping Review.Cureus · 2023Article
- Article
- Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice.Journal of neuroscience research · 2023Article
- World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation.Molecular neurobiology · 2023Article
- Indirect mediators of systemic health outcomes following nanoparticle inhalation exposure.Pharmacology & therapeutics · 2022Review
- Role of brain extracellular vesicles in air pollution-related cognitive impairment and neurodegeneration.Environmental research · 2022Review
- Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- The pathogenic effects of particulate matter on neurodegeneration: a review.Journal of biomedical science · 2022Review
- Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children.JAMA network open · 2021Article
- An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Should Nano-Particles be Weighed or Counted? Technical Considerations to In Vitro Testing Originated from Corpuscular Nature of Nano-Particles.Archivum immunologiae et therapiae experimentalis · 2021Review
- Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model.Environmental health perspectives · 2021Article
- Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion.Frontiers in immunology · 2021Article
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.Frontiers in aging neuroscience · 2021Article
- Nanoparticulate matter exposure results in white matter damage and an inflammatory microglial response in an experimental murine model.PloS one · 2021Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.