ArticlePloS one2018
Medial septal cholinergic mediation of hippocampal theta rhythm induced by vagal nerve stimulation.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- A Comprehensive Review of the Gut-Microbiota-Brain Axis in Alzheimer's Disease: From Pathophysiology to Potential Therapies.Pathogens (Basel, Switzerland) · 2026Review
- Vagus nerve stimulation (VNS) preventing postoperative cognitive dysfunction (POCD): two potential mechanisms in cognitive function.Molecular and cellular biochemistry · 2025Review
- Chemoarchitectural signatures of subcortical shape alterations in generalized epilepsy.Communications biology · 2024Article
- The gut-brain axis and cognitive control: A role for the vagus nerve.Seminars in cell & developmental biology · 2024Review
- Advances in VNS efficiency and mechanisms of action on cognitive functions.Frontiers in physiology · 2024Review
- Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer's disease intervention through the brain-gut-microbiota axis?Frontiers in aging neuroscience · 2024Review
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Signal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence.Biological psychology · 2023Review
- A brain cytokine-independent switch in cortical activity marks the onset of sickness behavior triggered by acute peripheral inflammation.Journal of neuroinflammation · 2023Article
- Transcutaneous Vagus Nerve Stimulation for Insomnia in People Living in Places or Cities with High Altitudes: A Randomized Controlled Trial.Brain sciences · 2023Article
- Article
- Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner.JCI insight · 2022Article
- Breathing Rhythm and Pattern and Their Influence on Emotion.Annual review of neuroscience · 2022Review
- Cholinergic Regulation of Hippocampal Theta Rhythm.Biomedicines · 2022Review
- Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.Frontiers in cellular neuroscience · 2022Article
- Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases.International journal of molecular sciences · 2021Review
- The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies.Frontiers in neural circuits · 2021Review
- Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy.Biomedicines · 2020Article
- Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation.Frontiers in cellular neuroscience · 2020Review
- Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.BMC anesthesiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrical vagal nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. This technique also remains under investigation as a specific treatment of patients with Alzheimer's disease. Recently we discovered that VNS induced hippocampal formation (HPC) type II theta rhythm, which is involved in memory consolidation. In the present study, we have extended our previous observation and addressed the neuronal substrate and pharmacological profile of HPC type II theta rhythm induced by VNS in anesthetized rats.
methodsMale Wistar rats were implanted with a VNS cuff electrode around the left vagus nerve, a tungsten microelectrode for recording the HPC field activity, and a medial septal (MS) cannula for the injection of a local anesthetic, procaine, and muscarinic agents. A direct, brief effect of VNS on the HPC field potential was evaluated before and after medial-septal drug injection.
resultsMedial septal injection of local anesthetic, procaine, reversibly abolished VNS-induced HPC theta rhythm. With the use of cholinergic muscarinic agonist and antagonists, we demonstrated that medial septal M1 receptors are involved in the mediation of the VNS effect on HPC theta field potential.
conclusionThe MS cholinergic M1 receptor mechanism integrates not only central inputs from the brainstem synchronizing pathway, which underlies the production of HPC type II theta rhythm, but also the input from the vagal afferents in the brain stem.
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