ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2019
Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Coexisting With Humans: Genomic and Behavioral Consequences in a Small and Isolated Bear Population.Molecular biology and evolution · 2025Article
- Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2025Review
- Review
- Metabolomics-Guided Genomic Comparisons Reveal Convergent Evolution of Hibernation Genes in Mammals.Molecular biology and evolution · 2025Article
- Linking Measures of Inbreeding and Genetic Load to Demographic Histories Across Three Species of Bears.Evolutionary applications · 2025Article
- Article
- Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Development of a Genotyping-in-Thousands by Sequencing (GT-Seq) Panel for Identifying Individuals and Estimating Relatedness Among Alaska Black Bears (Ecology and evolution · 2025Article
- A genome assembly of the American black bear, Ursus americanus, from California.The Journal of heredity · 2024Article
- Cognitive Impairment in Chronic Kidney Disease Is Associated with Glymphatic System Dysfunction.Kidney diseases (Basel, Switzerland) · 2023Article
- Genetic architecture and evolution of color variation in American black bears.Current biology : CB · 2023Article
- Sequencing and assembling bear genomes: the bare necessities.Frontiers in zoology · 2022Review
- A Beary Good Genome: Haplotype-Resolved, Chromosome-Level Assembly of the Brown Bear (Ursus arctos).Genome biology and evolution · 2022Article
- Uncovering the enigmatic evolution of bears in greater depth: The hybrid origin of the Asiatic black bear.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Long-read isoform sequencing reveals tissue-specific isoform expression between active and hibernating brown bears (Ursus arctos).G3 (Bethesda, Md.) · 2022Article
- Conservation of chromatin conformation in carnivores.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- An Annotated Draft Genome for the Andean Bear, Tremarctos ornatus.The Journal of heredity · 2021Article
- Environmental genomics of Late Pleistocene black bears and giant short-faced bears.Current biology : CB · 2021Article
- A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears.The Journal of surgical research · 2021Article
- Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears.Scientific reports · 2020Observational
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The prevalence of chronic kidney disease (CKD) is rising worldwide and 10-15% of the global population currently suffers from CKD and its complications. Given the increasing prevalence of CKD there is an urgent need to find novel treatment options. The American black bear (Ursus americanus) copes with months of lowered kidney function and metabolism during hibernation without the devastating effects on metabolism and other consequences observed in humans. In a biomimetic approach to better understand kidney adaptations and physiology in hibernating black bears, we established a high-quality genome assembly. Subsequent RNA-Seq analysis of kidneys comparing gene expression profiles in black bears entering (late fall) and emerging (early spring) from hibernation identified 169 protein-coding genes that were differentially expressed. Of these, 101 genes were downregulated and 68 genes were upregulated after hibernation. Fold changes ranged from 1.8-fold downregulation (RTN4RL2) to 2.4-fold upregulation (CISH). Most notable was the upregulation of cytokine suppression genes (SOCS2, CISH, and SERPINC1) and the lack of increased expression of cytokines and genes involved in inflammation. The identification of these differences in gene expression in the black bear kidney may provide new insights in the prevention and treatment of CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.