Evidence map›Paper›PMID 30395228›Full record

ArticleInternational health2019

The promise, problems and pitfalls of mass drug administration for malaria elimination: a qualitative study with scientists and policymakers.

Nils Kaehler, Bipin Adhikari, Phaik Yeong Cheah, Nicholas P J Day, Daniel H Paris, Marcel Tanner, Christopher Pell

Open access · hybridAbstract read
In one paragraph

Article in International health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  7. Article
  8. Mass Drug Administration: Contextual Factor Considerations.The American journal of tropical medicine and hygiene · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Mass drug administration for endemic scabies: a systematic review.Tropical diseases, travel medicine and vaccines · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Community engagement and ethical global health research.Global bioethics = Problemi di bioetica · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Nils KaehlerSwiss Tropical and Public Health Institute, Basel, Switzerland.
Bipin AdhikariMahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Phaik Yeong CheahMahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Nicholas P J DayMahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Daniel H ParisSwiss Tropical and Public Health Institute, Basel, Switzerland.
Marcel TannerSwiss Tropical and Public Health Institute, Basel, Switzerland.
Christopher PellAmsterdam Institute for Global Health and Development (AIGHD), Amsterdam Health Technology Centre, Tower C4, Paasheuvelweg 25, BP Amsterdam, The Netherlands.
Mahidol University · THSwiss Tropical and Public Health Institute · CHUniversity of Oxford · GBUniversity of Amsterdam · NL

Funding

Wellcome TrustWellcome Trust 096527Wellcome Trust 101148/Z/13/Z
6 · The paper itself

Abstract

backgroundThe emergence of artemisinin resistance in the Greater Mekong Subregion (GMS) has prompted urgent containment measures. One possible approach is mass drug administration (MDA). This article explores attitudes towards and perceptions of MDA for malaria elimination among policymakers and leading malariologists.

methodsThirty-two semistructured interviews (SSI) were conducted with policymakers (n=17) and principal investigators (n=15) selected based on their involvement in malaria prevention, control and elimination in the GMS. Interviews were audio recorded and transcribed for qualitative content (thematic) analysis using NVivo (QSR International, Doncaster, Victoria, Australia).

resultsResearchers and policymakers described reluctance and consequently delays to pilot MDA for malaria elimination. Most policymakers and some researchers reported concerns around the evidence base, citing a lack of data on its effectiveness and appropriate target populations. There were also worries about promoting resistance. Other issues included a previous lack of support from the World Health Organization, past MDAs, the remoteness of target populations and challenges explaining the rationale for MDA.

conclusionsThe complex rationale for MDA for malaria elimination, mistaking pilot studies for implementation, past experiences with MDA, difficulties in selecting appropriate sites and the WHO's lack of clear backing undermined the support for MDA for malaria elimination.

Indexed as

Mass Drug AdministrationAdministrative PersonnelAntimalarialsAustraliaDisease EradicationDrug ResistanceHumansMalariaQualitative ResearchResearch PersonnelAntimalarialscommunity engagementeliminationgovernancemalaria controlpolicy

Identifiers

PMID30395228
PMCPMC6484636
OpenAlexW2903798425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.