Observational studyPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2019
Associations of Perioperative Renal Oximetry Via Near-Infrared Spectroscopy, Urinary Biomarkers, and Postoperative Acute Kidney Injury in Infants After Congenital Heart Surgery: Should Creatinine Continue to Be the Gold Standard?
Observational study in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Novel biomarkers for acute kidney injury in high-risk pediatric populations: a systematic review.Renal failure · 2026Pooled it
- Perioperative Monitoring of Regional Oxygen Saturation in Congenital Heart Disease: Systematic Review of Literature up to 2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Pooled it
- Putting the pieces together: solving the puzzle of early acute kidney injury post pediatric cardiac surgery.Pediatric research · 2026Article
- Intraoperative renal and cerebral tissue oxygen saturation measurements to predict postoperative acute kidney injury in pediatric cardiac surgery: a prospective observational study.Journal of clinical monitoring and computing · 2026Observational
- Comparison of Near-Infrared Spectroscopy and Traditional Parameters for Monitoring Neonates with Aortic Coarctation.Pediatric cardiology · 2026Article
- The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit.Pediatric nephrology (Berlin, Germany) · 2025Review
- Decreased renal or cerebral oxygen saturation increases the risk of cardiac surgery-associated acute kidney injury in adult patients: a prospective observational study.BMC anesthesiology · 2025Observational
- Evaluation of a low-cost portable NIRS device for monitoring muscle ischemia.Journal of clinical monitoring and computing · 2025Article
- Utilizing mesenteric near-infrared reflectance spectroscopy to predict gastrointestinal complication risks and optimize feeding strategies in infants undergoing cardiac surgery.Pediatric investigation · 2024Article
- Noninvasive Tools to Predict Necrotizing Enterocolitis in Infants with Congenital Heart Diseases: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Fluid Overload and AKI After the Norwood Operation: The Correlation and Characterization of Routine Clinical Markers.Pediatric cardiology · 2024Article
- Gut microbiota and neonatal acute kidney injury biomarkers.Pediatric nephrology (Berlin, Germany) · 2023Review
- Association of intraoperative cerebral and somatic tissue oxygen saturation with postoperative acute kidney injury in adult patients undergoing multiple valve surgery.BMC anesthesiology · 2023Article
- The Potential Use of Near- and Mid-Infrared Spectroscopy in Kidney Diseases.International journal of molecular sciences · 2023Review
- Impact on Renal Function and Hospital Outcomes of an Individualized Management of Cardiopulmonary Bypass in Congenital Heart Surgery: A Pilot Study.Pediatric cardiology · 2021Article
- The Relationships of Cerebral and Somatic Oxygen Saturation with Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass: Analysis Using the Random-Effects Model.Pediatric cardiology · 2021Observational
- Patterns of Urinary Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury in Neonates Receiving Cardiopulmonary Bypass.Children (Basel, Switzerland) · 2020Article
- Regional tissue oxygenation monitoring in the neonatal intensive care unit: evidence for clinical strategies and future directions.Pediatric research · 2019Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectivesExamine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass.
designProspective, observational.
settingCardiac operating room and cardiac ICU. PATIENTS: Neonates and infants without history of kidney injury or anatomic renal abnormality.
interventionsNone. MEASUREMENTS AND MAIN
resultsRenal regional tissue oximetry was measured intraoperatively and for 48 hours postoperatively. Urinary levels of neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinases 2 together with insulin-like growth factor-binding protein 7 were measured preoperatively, 2, 12, and 24 hours postoperatively. Patients were categorized as no acute kidney injury, stage 1, or Stage 2-3 acute kidney injury using the Kidney Disease: Improving Global Outcomes criteria with 43 of 70 (61%) meeting criteria for any stage acute kidney injury. Stage 2-3 acute kidney injury patients had higher tissue inhibitor of metalloproteinases 2, insulin-like growth factor-binding protein 7 at 2 hours (0.3 vs 0.14 for stage 1 acute kidney injury and 0.05 for no acute kidney injury; p = 0.052) and 24 hours postoperatively (1.71 vs 0.27 for stage 1 acute kidney injury and 0.19 for no acute kidney injury, p = 0.027) and higher neutrophil gelatinase-associated lipocalin levels at 24 hours postoperatively (10.3 vs 3.4 for stage 1 acute kidney injury and 6.2 for no acute kidney injury, p = 0.019). Stage 2-3 acute kidney injury patients had lower mean cardiac ICU renal regional tissue oximetry (66% vs 79% for stage 1 acute kidney injury and 84% for no acute kidney injury, p = 0.038). Regression analyses showed that tissue inhibitor of metalloproteinases 2, insulin-like growth factor-binding protein 7 at 2 hours postoperatively and nadir intraoperative renal regional tissue oximetry to be independent predictors of postoperative kidney damage as measured by urinary neutrophil gelatinase-associated lipocalin.
conclusionsWe observed modest differences in perioperative renal regional tissue oximetry and urinary biomarker levels compared between acute kidney injury groups classified by creatinine-dependent Kidney Disease: Improving Global Outcomes criteria, but there were significant correlations between renal regional tissue oximetry, tissue inhibitor of metalloproteinases 2, insulin-like growth factor-binding protein 7, and postoperative neutrophil gelatinase-associated lipocalin levels. Kidney injury after infant cardiac surgery may be undetectable by functional assessment (creatinine) alone, and continuous monitoring of renal regional tissue oximetry may be more sensitive to important subclinical acute kidney injury.
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