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The Fragility and Reliability of Conclusions of Anesthesia and Critical Care Randomized Trials With Statistically Significant Findings: A Systematic Review.
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What the available source describes
Study context is available. A quantitative result is not established here.
Study context 1 · source-backed descriptions
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Who or what was studied
anesthesia and critical care randomized controlled trials
What was examined
statistically significant results
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- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
The median Fragility Index was 3 (interquartile range, 1-7), which means that adding three events to one of the trials treatment arms eliminated its statistical significance.
- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
Our objectives were to calculate the Fragility Index of statistically significant results from randomized controlled trials of anesthesia and critical care interventions and to determine the frequency of distorted presentation of results or "spin".
- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
CONCLUSIONS: Statistically significant results in anesthesia and critical care randomized controlled trials are often fragile, and study conclusions are frequently affected by spin.
Study context 2 · source-backed descriptions
No supported numerical result is available for this comparison. No supported numeric visual is available.
Who or what was studied
anesthesia and critical care randomized controlled trials
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- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
High spin was identified in 42% (n = 30) of negative randomized controlled trials, whereas 21% (n = 20) of positive randomized controlled trials provided recommendations.
- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
CONCLUSIONS: Statistically significant results in anesthesia and critical care randomized controlled trials are often fragile, and study conclusions are frequently affected by spin.
Study context 3 · source-backed descriptions
No supported numerical result is available for this comparison. No supported numeric visual is available.
Who or what was studied
anesthesia and critical care randomized controlled trials
Outcome named in the source
levels of spin and recommendations
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- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
Lower levels of spin and recommendations were associated with publication in journals with high impact factors (p < 0.001 for both).
- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
CONCLUSIONS: Statistically significant results in anesthesia and critical care randomized controlled trials are often fragile, and study conclusions are frequently affected by spin.