Evidence map›Paper›PMID 30394854›Full record

ArticleMolecular imaging

Development and Characterization of an

Ahmed Abbas, Lihai Yu, Tyler Lalonde, Derek Wu, Jonathan D Thiessen, Leonard G Luyt, Savita Dhanvantari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed Abbas1 Department of Medical Biophysics, Western University, London, Ontario, Canada.ORCID 0000-0001-5107-5924
Lihai Yu2 Department of Chemistry, Western University, London, Ontario, Canada.
Tyler Lalonde2 Department of Chemistry, Western University, London, Ontario, Canada.
Derek Wu3 Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Jonathan D Thiessen1 Department of Medical Biophysics, Western University, London, Ontario, Canada.
Leonard G Luyt2 Department of Chemistry, Western University, London, Ontario, Canada.
Savita Dhanvantari1 Department of Medical Biophysics, Western University, London, Ontario, Canada.ORCID 0000-0001-6453-1386

Funding

CIHR
6 · The paper itself

Abstract

One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular abnormalities that can lead to heart failure, and circulating biomarkers are not cardiac specific. Thus, there is critical need for biomarkers that are endogenous to myocardial tissues. The cardiac growth hormone secretagogue receptor 1a (GHSR1a), which binds the hormone ghrelin, is a potential biomarker for heart failure. We have synthesized and characterized a novel ghrelin peptidomimetic tracer, an

Indexed as

AnimalsBiomarkersCell Line, TumorFastingFeeding BehaviorFemaleFluorine RadioisotopesGhrelinGlucagonGlucagon-Like Peptide 1HumansInsulinMice, Inbred C57BLMyocardiumPeptidomimeticsPositron Emission Tomography Computed TomographyBiomarkersFluorine RadioisotopesGhrelinGlucagonGlucagon-Like Peptide 1InsulinPeptidomimeticsReceptors, GhrelinbiomarkerscardiacghrelinGHSR1aheart diseaseheart failureimagingPET

Identifiers

PMID30394854
PMCPMC6236854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.