Evidence map›Paper›PMID 30394839›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2019

Acute administration of tirofiban versus aspirin in emergent carotid artery stenting.

Philipp Gruber, Martin Hlavica, Jatta Berberat, Benjamin Victor Ineichen, Michael Diepers, Krassen Nedeltchev, Timo Kahles, Luca Remonda

Abstract read
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Tirofiban for acute ischemic stroke: systematic review and meta-analysis.European journal of clinical pharmacology · 2020
    Pooled it
  4. Letter to the Editor.Clinical neuroradiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. [Drug therapy for acute and elective stent angioplasty].Radiologie (Heidelberg, Germany) · 2024
    Article
  9. Article
  10. Article
  11. Safety and efficacy of symptomatic carotid artery stenting performed in an emergency setting.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Philipp Gruber1 Department of Neuroradiology, Cantonal Hospital Aarau, Aarau, Switzerland.
Martin Hlavica1 Department of Neuroradiology, Cantonal Hospital Aarau, Aarau, Switzerland.
Jatta Berberat1 Department of Neuroradiology, Cantonal Hospital Aarau, Aarau, Switzerland.
Benjamin Victor Ineichen3 Brain Research Institute, University of Zurich, Zurich, Switzerland.
Michael Diepers1 Department of Neuroradiology, Cantonal Hospital Aarau, Aarau, Switzerland.
Krassen Nedeltchev2 Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland.
Timo Kahles2 Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland.
Luca Remonda5 Department of Neuroradiology, Cantonal Hospital Aarau, Aarau, University of Bern, Switzerland.
Kantonsspital Aarau · CHETH Zurich · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarotid artery stenting requires antiplatelet therapy for prevention of in-stent thrombosis. Patients suffering from acute ischemic stroke undergoing intravenous thrombolysis and emergent carotid artery stenting (eCAS) are at high risk for intracranial bleeding. We assessed efficacy and safety of acute administration of intravenous tirofiban versus aspirin in these patients.

methodsA retrospective, single center, cohort study was carried out of 32 patients who underwent eCAS (18 received tirofiban, 14 received aspirin) at our comprehensive stroke center (2008-2016).

resultsOf our 32 consecutive eCAS patients, favorable clinical outcomes (modified Rankin scale ≤ 2) were achieved in eight (47%) tirofiban patients and six (46%) aspirin patients ( p = 0.96). Overall rates were similar for symptomatic intracranial bleeding (tirofiban 22%, aspirin 29%, p = 0.68) and mortality (tirofiban 18%, aspirin 23%, p = 0.71).

conclusionsTirofiban and aspirin demonstrated similar efficacy and safety in thrombolyzed stroke patients who underwent eCAS in our cohort. Intravenous tirofiban with its short half-life might represent an alternative to aspirin in select patients.

Indexed as

StentsAgedAspirinCarotid StenosisCerebral AngiographyFemaleFibrinolytic AgentsHumansMaleMiddle AgedRetrospective StudiesStrokeTirofibanTomography, X-Ray ComputedTreatment OutcomeAspirinFibrinolytic AgentsTirofibanemergent carotid artery stentingstrokeTirofiban

Identifiers

PMID30394839
PMCPMC6448368
OpenAlexW2898705986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.