Evidence map›Paper›PMID 30394397›Full record

ArticleJournal of visualized experiments : JoVE2018

Transdermal Measurement of Glomerular Filtration Rate in Mice.

Lauren Scarfe, Daniel Schock-Kusch, Lorenzo Ressel, Jochen Friedemann, Yury Shulhevich, Patricia Murray, Bettina Wilm, Mark de Caestecker

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
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  5. Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026
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  11. Ovarian hormones moderate systolic hypertension in femaleAmerican journal of physiology. Renal physiology · 2026
    Article
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  15. Modulatory effects of exogenous estradiol during endotoxemia.The international journal of biochemistry & cell biology · 2026
    Article
  16. Article
  17. Claudin-3 is expressed at theFrontiers in physiology · 2026
    Article
  18. Article
  19. Article
  20. Ovarian Hormones Moderate Systolic Hypertension in FemalebioRxiv : the preprint server for biology · 2025
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lauren ScarfeDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center; Department of Cellular and Molecular Physiology, University of Liverpool.
Daniel Schock-KuschMediBeacon GmbH; dschock-kusch@medibeacon.com.
Lorenzo ResselDepartment of Veterinary Pathology and Public Health, Institute of Veterinary Science, University of Liverpool.
Jochen FriedemannMediBeacon GmbH.
Yury ShulhevichMediBeacon GmbH.
Patricia MurrayDepartment of Cellular and Molecular Physiology, University of Liverpool.
Bettina WilmDepartment of Cellular and Molecular Physiology, University of Liverpool; b.wilm@liverpool.ac.uk.
Mark de CaesteckerDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center; mark.de.caestecker@Vanderbilt.Edu.
University of Liverpool · GBMedibeacon (United States) · USVanderbilt University Medical Center · US

Funding

Mechanisms and therapeutic manipulation of retinoic acid signaling in Acute Kidney InjuryR01DK112688 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2020
$1.7M
Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/K026739/1
6 · The paper itself

Abstract

Transdermal analysis of glomerular filtration rate (GFR) is an established technique that is used to assess renal function in mouse and rat models of acute kidney injury and chronic kidney disease. The measurement system consists of a miniaturized fluorescence detector that is directly attached to the skin on the back of conscious, freely moving animals, and measures the excretion kinetics of the exogenous GFR tracer, fluorescein-isothiocyanate (FITC) conjugated sinistrin (an inulin analog). This system has been described in detail in rats. However, because of their smaller size, measurement of transcutaneous GFR in mice presents additional technical challenges. In this paper we therefore provide the first detailed practical guide to the use of transdermal GFR monitors in mice based on the combined experience of three different investigators who have been performing this assay in mice over a number of years.

Indexed as

Administration, CutaneousAnimalsGlomerular Filtration RateMaleMice

Identifiers

PMID30394397
PMCPMC6235579
OpenAlexW2896613080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.