ArticleDevelopment and psychopathology2019
Self-injuring adolescent girls exhibit insular cortex volumetric abnormalities that are similar to those seen in adults with borderline personality disorder.
Article in Development and psychopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343039 (Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- A Comparative Analysis of Cortical Thickness in Female Youth With Non-Suicidal Self-Injury.Psychiatry investigation · 2026Article
- Structural-functional connectivity decoupling reveals neural differences associated with subtypes of nonsuicidal self-injury among female depressive adolescents.Frontiers in psychiatry · 2026Article
- Nonsuicidal self-injury prediction with pain-processing neural circuits using interpretable graph neural network.Annals of medicine · 2025Article
- Altered cortical structure and networks associated with psychosocial adversity and pain hyposensitivity in adolescents with non-suicidal self-injury.BMC psychiatry · 2025Article
- Altered local gyrification index and corresponding functional connectivity in female depressed adolescents with suicide attempts and non-suicidal self-injury.Psychoradiology · 2025Article
- A preliminary investigation into cortical structural alterations in adolescents with nonsuicidal self-injury.Psychiatry research. Neuroimaging · 2023Article
- Electroacupuncture alleviates the relapse of pain-related aversive memory by activating KOR and inhibiting GABAergic neurons in the insular cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Risk factors, theoretical models, and biological mechanisms of nonsuicidal self-injury: a brief review.Interdisciplinary nursing research · 2023Review
- Examining the Construct Validity of Borderline Personality Traits Using Familial Aggregation and Other External Validators.Journal of personality disorders · 2022Article
- Superior temporal gyrus and cerebellar loops predict nonsuicidal self-injury in major depressive disorder patients by multimodal neuroimaging.Translational psychiatry · 2022Article
- Elevated levels of monocyte-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with non-suicidal self-injury.BMC psychiatry · 2022Article
- Peripheral and neural correlates of self-harm in children and adolescents: a scoping review.BMC psychiatry · 2022Article
- Neuroimaging Studies of Nonsuicidal Self-Injury in Youth: A Systematic Review.Life (Basel, Switzerland) · 2021Review
- [Neurobiological principles of borderline personality disorder: integration into the ICD-11 model of personality disorders].Der Nervenarzt · 2021Review
- Brain structure and parasympathetic function during rest and stress in young adult women.Brain structure & function · 2021Article
- Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth.Biological psychiatry · 2021Review
- Moving beyond Ordinary Factor Analysis in Studies of Personality and Personality Disorder: A Computational Modeling Perspective.Psychopathology · 2020Review
- Nonsuicidal Self-Injury and Suicidal Behaviors in Girls: The Case for Targeted Prevention in Preadolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Self-inflicted injury (SII) in adolescence is a serious public health concern that portends prospective vulnerability to internalizing and externalizing psychopathology, borderline personality development, suicide attempts, and suicide. To date, however, our understanding of neurobiological vulnerabilities to SII is limited. Behaviorally, affect dysregulation is common among those who self-injure. This suggests ineffective cortical modulation of emotion, as observed among adults with borderline personality disorder. In borderline samples, structural and functional abnormalities are observed in several frontal regions that subserve emotion regulation (e.g., anterior cingulate, insula, dorsolateral prefrontal cortex). However, no volumetric analyses of cortical brain regions have been conducted among self-injuring adolescents. We used voxel-based morphometry to compare cortical gray matter volumes between self-injuring adolescent girls, ages 13-19 years (n = 20), and controls (n = 20). Whole-brain analyses revealed reduced gray matter volumes among self-injurers in the insular cortex bilaterally, and in the right inferior frontal gyrus, an adjacent neural structure also implicated in emotion and self-regulation. Insular and inferior frontal gyrus gray matter volumes correlated inversely with self-reported emotion dysregulation, over-and-above effects of psychopathology. Findings are consistent with an emotion dysregulation construal of SII, and indicate structural abnormalities in some but not all cortical brain regions implicated in borderline personality disorder among adults.
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