Evidence map›Paper›PMID 30393967›Full record

ArticlePhysiological reports2018

Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep.

Severin Ruoss, Philipp Kindt, Linus Oberholzer, Marco Rohner, Ladina Jungck, Sara Abdel-Aziz, Daniel Fitze, Andrea B Rosskopf, Karina Klein, Brigitte von Rechenberg and 3 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Large animal models for the study of tendinopathy.Frontiers in cell and developmental biology · 2022
    Review
  5. Article
  6. Animal models for study on rotator cuff injury.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Severin RuossLaboratory for Muscle Plasticity, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8896-635X
Philipp KindtVetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Linus OberholzerLaboratory for Muscle Plasticity, University of Zurich, Zurich, Switzerland.
Marco RohnerLaboratory for Muscle Plasticity, University of Zurich, Zurich, Switzerland.
Ladina JungckLaboratory for Muscle Plasticity, University of Zurich, Zurich, Switzerland.
Sara Abdel-AzizLaboratory for Muscle Plasticity, University of Zurich, Zurich, Switzerland.
Daniel FitzeLaboratory for Muscle Plasticity, University of Zurich, Zurich, Switzerland.
Andrea B RosskopfFaculty of Medicine, University of Zurich, Zurich, Switzerland.
Karina KleinVetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Brigitte von RechenbergVetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Christian GerberCompetence Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zurich, Zurich, Switzerland.
Karl WieserDepartment of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Martin FlückFaculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0479-7243
University of Zurich · CH

Funding

Swiss National Science Foundation 149786
6 · The paper itself

Abstract

Chronic rotator cuff (RC) tears are characterized by retraction, fat accumulation, and atrophy of the affected muscle. These features pose an intractable problem for surgical repair and subsequent recovery, and their prevention may be easier than reversal. Using an established ovine model, we tested the hypothesis that inhibition of the protease calpain mitigates m. infraspinatus atrophy by preservation of the myofibers' structural anchors in the sarcolemma (the costameres). Already 2 weeks of distal tendon release led to a reduction in muscle volume (-11.6 ± 9.1 cm

Indexed as

AnimalsCalpainCysteine Proteinase InhibitorsDipeptidesFemaleMuscular AtrophyRotator Cuff InjuriesSarcolemmaSheepCalpaincalpeptinCysteine Proteinase InhibitorsDipeptidesAtrophycalpaincostamererotator cuff teartenotomy

Identifiers

PMID30393967
PMCPMC6215759
OpenAlexW2900202434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.