ArticleCommunications biology2018
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.
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Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
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Who cites it
112 citing papers in PubMed, 174 citations in OpenAlex.
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- Translational resistance to amino acid starvation in breast cancer cells revealed by ribosome profiling.iScience · 2026Article
- Tumoral Metabolism at the Intersection of Oncogene Signaling, Epigenetics and Immunology: Emerging Therapeutic Strategies in Cancer.Current issues in molecular biology · 2026Review
- Arginine metabolism supportsmBio · 2026Article
- Dysregulation of the urea cycle - potential targets for treatment and diagnosis in prostate cancer.Expert reviews in molecular medicine · 2026Review
- Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model.Fluids and barriers of the CNS · 2026Article
- Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase.Nature metabolism · 2026Article
- Amino Acids as Targets for Immunotherapy against Solid Tumors.Cell biochemistry and biophysics · 2026Review
- A novel recombinant arginine deiminase from Limosilactobacillus reuteri DSM 20016 demonstrates anticancer activity against colon cancer cells.Molecular biology reports · 2026Article
- Macrophage-intrinsic and IL-9-dependent arginine metabolism promotes lung tumor growth.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Article
- Metabolic permissiveness: how tissue context shapes cancer.Genes & development · 2026Review
- A vicious cycle inducer in gastric pathogenesis: implication of Helicobacter pylori.Archives of microbiology · 2026Review
- Decoding amino acid metabolism in hepatocellular carcinoma: critical nodes and novel therapeutic strategy.Frontiers in oncology · 2026Review
- L-arginine metabolism in breast cancer: mechanisms and therapeutic targets.Frontiers in oncology · 2026Review
- Molecular mechanisms and therapies for tumor inhibition through the arginine metabolism pathway.Frontiers in oncology · 2026Review
- Amino acids metabolism: a potential target for cancer treatment.Molecular cancer · 2025Review
- Targeting autophagy and metabolism for ewing sarcoma.Molecular biology reports · 2025Review
- Identification of SLC7A1 as a potential therapeutic target for high-grade meningioma.Cell death discovery · 2025Article
- Arginine Metabolism SupportsbioRxiv : the preprint server for biology · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 5 institutions in 2 countries.
Chun-Ting ChengDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Yue QiDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Yi-Chang WangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Kevin K ChiDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Yiyin ChungDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Ching OuyangDepartment of Information Sciences, City of Hope, Duarte, CA, 91010, USA.ORCID http://orcid.org/0000-0002-7452-2800
Yun-Ru ChenDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Myung Eun OhDepartment of Molecular and Cellular Endocrinology, City of Hope, Duarte, CA, 91010, USA.
Xiangpeng ShengDepartment of Molecular and Cellular Endocrinology, City of Hope, Duarte, CA, 91010, USA.
Yulong TangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Yun-Ru LiuOffice of Human Research, Center for Cancer Research, Taipei Medical University, Taipei City, Taiwan.
H Helen LinDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Ching-Ying KuoDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Dustin SchonesDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Christina M VidalDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA.
Jenny C-Y ChuInstitute for Translational Medicine, Taipei Medical University, Taipei City, Taiwan.
Hung-Jung WangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan.
Yu-Han ChenUC Irvine Diabetes Center, University of California at Irvine, Irvine, CA, 92697, USA.
Kyle M MillerDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID http://orcid.org/0000-0002-4544-0013
Peiguo ChuShared Pathology Core, City of Hope, Duarte, CA, 91010, USA.
Yun YenOffice of Human Research, Center for Cancer Research, Taipei Medical University, Taipei City, Taiwan.
Lei JiangDepartment of Molecular and Cellular Endocrinology, City of Hope, Duarte, CA, 91010, USA.
Hsing-Jien KungInstitute for Translational Medicine, Taipei Medical University, Taipei City, Taiwan. hkung@nhri.org.tw.
David K AnnDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, 91010, USA. dann@coh.org.
City of Hope · USTaipei Medical University · TWUniversity of California, Irvine · USNational Health Research Institutes · TWThe University of Texas at Austin · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MMOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSIONR01DE010742 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANN, DAVID K. · 1993 to 2013
$5.1MEpigenetic damage in women living in LA food-desert zip codesR01CA220693 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K., HYSLOP, TERRY · 2017 to 2021
$3.7MMechanisms for Salivary Tumor Epithelial-Mesenchymal TransitionsR01DE026304 · NIDCR · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K., LIN, HER HELEN · 2016 to 2020
$2.1MMolecular Characterization of Autophagy in Salivary Gland TumorsR21DE023298 · NIDCR · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K. · 2013 to 2014
$462kNCI NIH HHS P30 CA033572NCI NIH HHS R01 CA220693NIDCR NIH HHS R01 DE010742NIDCR NIH HHS R01 DE026304NIDCR NIH HHS R21 DE023298
Abstract
Defective arginine synthesis, due to the silencing of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.