ArticleRomanian journal of anaesthesia and intensive care2018
The relationship between labor pain management, cortisol level and risk of postpartum depression development: a prospective nonrandomized observational monocentric trial.
Article in Romanian journal of anaesthesia and intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The association between labor epidural analgesia and postpartum depression: a systematic review and meta-analysis.BMC women's health · 2020Pooled it
- Low-dose esketamine with sufentanil for postcesarean analgesia in women with gestational diabetes mellitus: a prospective, randomized, double-blind study.Frontiers in endocrinology · 2023Trial
- Association between epidural analgesia experience and future fertility intention in China: a national cross-sectional study.BMJ open · 2026Article
- The impact of combined spinal-epidural analgesia (CSEA) on postpartum depression: A Mendelian randomization study.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Influence of Neuraxial Anesthesia Technique During Vaginal and Cesarean Delivery and Association with Postpartum Depression: A Narrative Review of Literature.Neuropsychiatric disease and treatment · 2026Review
- The role of anesthesiologists in postpartum depression: current perspectives and future directions.Frontiers in psychiatry · 2025Review
- Review
- Association between epidural analgesia and postpartum psychiatric disorders: A meta-analysis.Heliyon · 2024Article
- Obstetric anesthesia clinic childbirth course combined with labor epidural analgesia is associated with a decreased risk of postpartum depression : a prospective cohort study.BMC anesthesiology · 2022Article
- Childbirth Pain, Labor Epidural Analgesia, and Postpartum Depression: Recent Evidence and Future Directions.Journal of pain research · 2022Review
- Effect of epidural labor analgesia on maternal and infant outcomes in parturients with gestational diabetes mellitus-A prospective cohort study.Frontiers in pediatrics · 2022Article
- Relationship between delivery with anesthesia and postpartum depression: The Japan Environment and Children's Study (JECS).BMC pregnancy and childbirth · 2021Article
- Perinatal depression.International anesthesiology clinics · 2021Article
- The association between labour epidural analgesia and postpartum depressive symptoms: a longitudinal cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Observational
- Non-pharmacological labor pain management and associated factor among skilled birth attendants in Amhara Regional State health institutions, Northwest Ethiopia.Reproductive health · 2020Article
- Pharmacologic labour analgesia and its relationship to postpartum psychiatric disorders: a scoping review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Article
- Labor Pain, Analgesia, and Postpartum Depression: Are We Asking the Right Questions?Anesthesia and analgesia · 2020Article
- The Trend of Labor Analgesia in the World and China: A Bibliometric Analysis of Publications in Recent 30 Years.Journal of pain research · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postpartum depression (PPD) is the main psychological status disorder and women suffering from postpartum depression often need long-term psychological and socio-economic rehabilitation. The study is dedicated to the evaluation of the role of labor pain management using epidural analgesia in natural delivery on stress level in labor and frequency of postnatal depression. MATERIALS AND
methods210 women were investigated and divided into two groups. In the first group for labor pain management in natural delivery, patient-controlled epidural analgesia was used (bolus - 10.0 - 0.08% ropivacaine hydrochloride, lockout - 30 min, limit - 120 ml/6 h) with a background of continuous-flow infusion of local anesthetic 0.08% ropivacaine hydrocluoride solution. Patients in the second group had no pain relief in delivery. The stress level was evaluated using blood plasma cortisol level in the early stages of labor, 6 hours and 3 days after delivery. The assessment of depression development was carried out step-by-step: Before the delivery, 6 hours after, 3 days and 6 weeks after the delivery.
resultsThe baby blues frequency 6 hours after the delivery in the group where the pain relief was conducted was 29.91%, with cortisol level below and equal to 2310.91 nmol/l. In the group with no pain relief 6 hours after delivery, baby blues was found in 15.53% of puerperas (p < 0.05) and the cortisol level was 2673.82 nmol/l (p < 0.05). Six weeks after the birth, postpartum depression was diagnosed in 4.67% of women who received epidural analgesia during delivery, in comparison to 6.79% with no pain relief during delivery. However, the difference was not statistically significant (p < 0.05).
conclusionsThe use of epidural analgesia leads to a significant reduction of pain syndrome and stress response during natural delivery, increases the risk of baby blues in the early postnatal period, but slightly influences the frequency of postpartum depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.