ArticleRomanian journal of anaesthesia and intensive care2018
Rotational thromboelastometry (ROTEM) 24 hours post liver transplantation predicts early allograft dysfunction.
Article in Romanian journal of anaesthesia and intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Comprehensive coagulation and fibrinolytic potential in the acute phase of pediatric patients with idiopathic nephrotic syndrome evaluated by whole blood-based rotational thromboelastometry.Pediatric nephrology (Berlin, Germany) · 2022Article
- Using Rotational Thromboelastometry to Identify Early Allograft Dysfunction after Living Donor Liver Transplantation.Journal of clinical medicine · 2021Article
- A panel of biomarkers in the prediction for early allograft dysfunction and mortality after living donor liver transplantation.American journal of translational research · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
Early allograft dysfunction (EAD) represents one of the most common and serious complications after liver transplantation (LT).
methodsOne hundred sixty-four patients who underwent LT were prospectively included in the present study. Patient demographics, intraoperative blood loss and transfusion were recorded at the time of LT. Lactate levels were recorded during surgery and daily for the first 3 postoperative days. Standard and derived rotational thromboelastometry (ROTEM) parameters were recorded 24 hours after LT. EAD was diagnosed according to Nanashima criteria and post anaesthesia care unit length of stay was recorded.
resultsForty-seven patients (28.6%) developed EAD. Intraoperative blood loss (p = 0.01), packed red blood cells (p = 0.04) and fresh frozen plasma (p = 0.01) transfusion represented intraoperative risk factors for EAD. Lactate levels were significantly higher in patients with EAD at all time points. Patients with EAD demonstrated an increased clot formation time and decreased maximum clot firmness in both intrinsically (p < 0.01) and extrinsically (p < 0.01) activated assay, a decreased thrombin potential index (p < 0.01), area under the curve (p < 0.01) and clot elasticity (p < 0.01) on ROTEM assay.
conclusionOur results show that both standard and derived ROTEM parameters may indicate early signs of graft failure and can aid in the diagnosis of EAD.
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